List of searches and offers

Type: Search

Search
Partner Role:
Partner
Topic of the idea:
Functionalized metal nanoparticles used as anticancer agents
Other information:
Description of project idea:
Nanoparticles (NPs) of various types have been developed as therapeutic, diagnostic and curative agents for use in nanomedicine. There is evidence that metal NPs, such as gold, silver, copper or iron, could be used in nanomedicine. For example, gold NPs are possible anti-cancer agents (used in diagnosis and treatment); silver ones are possible radiosensitizers, vectors or antiviral drug carriers; cooper NPs may be anti-inflammatory, anti-proliferative, biocidal agents, but may be used in nuclear imaging and radiotherapy, and iron NPs can be used as markers in medical imaging. The in vivo efficacy of NPs is closely related to their physicochemical characteristics, so the functionalization of nanoparticles is a very current topic. We propose the biophysical characterization of some types of NPs by structural and spectrophotometric methods because it can contribute substantially to the understanding of the functioning mechanisms of NPs interacting with bio systems (biomolecules, membrane or cellular structures).
Our system allows hyperspectral analysis at the pixel level for any type of metallic or polymeric nanoparticles functionalized or no, targeted for drug delivery and related theranostic applications. Our target is to investigate cancer treatment and toxic effects of the drugs.
The nanoparticles interaction with living cells is monitored using the 3D scanning on Cytoviva system to visualize the nanoparticles position relative to the nucleus membrane. Their penetration inside cells/nucleus will be investigated in a noninvasive, marker free manner.
Already involved partners, if any (roles/competences):

Polytechnic University of Bucharest, Faculty of Applied Sciences, Department of Physics

Partners sought (roles/competences):
Hyperspectral microscopy expertize
Analysis of transparent biological samples by optical phase technique

Type: Offer

Offer
Partner Role:
Partner
Topic of the offer:
SERMAS has an extensive experience in European projects, having participated in 25 H2020 projects. Madrid Region has the second best Health System in the European Union, according to the European Commission’s latest Regional Competitiveness Index. Madrid Region Health System (SERMAS) assures the adequate coverage of more than 6.8 million people, including the capital, the third largest city in the EU. SERMAS includes it its network 37 hospitals, 265 primary care centres.
Other information:
  • First name, Surname: PILAR GANGAS
  • Institution/organisation: MADRID HEALTH SYSTEM (SERMAS)-FIIBAP (Madrid Primary Health Care Foundation)
  • Country: SPAIN
  • E-mail: PILAR.GANGAS@SALUD.MADRID.ORG
  • Website: WWW.FIIBAP.ORG
Competences offered:
- Scientific research
- Methodology of pilots
- Pilots implementation involving patients, caregivers, health professionals
- Project management
We can connect an ongoing consortium with the Madrid region biomedical research groups (primary health care or hospital specialized health care) required for the project.
Offer
Partner Role:
Partner
Topic of the offer:
Physico-chemical characterization of nanoparticles, analytical method development and validation.

Other information:
  • First name, Surname: Marlène Klein
  • Institution/organisation: ADERA/UT2A
  • Country: France
  • E-mail: marlene.klein@univ-pau.fr
  • Website: www.ut2a.fr
Competences offered:
- Multi-dimensional physico-chemical characterization of polymers and nanoformulations by A4F-UV-MALS-(RI or ICPMS) online : granulometry (size, size distribution), shape, aggregation state, stability, encapsulation efficiency, chemical composition
- Determination of size and concentration of metallic nanoparticles by Single particle ICPMS
- Granulometry by DLS according to ISO reference document.
- Analytical method development and validation expertise in a nearly GLP implemented environment together with external QA audits.
- Trace metals impurities in pharmaceutical products according to ICHQ3D
- Speciation and trace metal analysis by HPLC and GC-ICPMS
Offer
Partner Role:
Partner
Topic of the offer:
- Diagnostics
- Targeted delivery systems
Other information:
  • First name, Surname: Jose A. Costoya, M.D., Ph.D.
  • Institution/organisation: USC
  • Country: Spain
  • E-mail: josea.costoya@usc.es
  • Website: https://www.usc.es/cimus/en
Competences offered:
- 2D and 3D (tumoroids/organoids) in vitro cancer models.
- Generation and characterization of genetically modified mouse models of cancer as a tool to study the molecular basis of disease pathogenesis, as well as a preclinical model for designing and validating new diagnostic (biomarkers) and therapeutic approaches (drug discovery).
- Design of non-invasive systems for in vivo monitoring and follow-up of the entire pathological processes.
Offer
Partner Role:
Partner
Topic of the offer:
a) Regenerative medicine
b) Diagnostics
c) Targeted delivery systems
Other information:
  • First name, Surname: Mireia Gimenez
  • Institution/organisation: LEITAT
  • Country: España
  • E-mail: mgimenez@leitat.org
  • Website: https://projects.leitat.org/
Competences offered:
-Design, synthesis and characterization of NP of inorganic and organic nature (self-assembly, polymeric FDA-approved, gold, etc).

- Control and sustained release, Targeted delivery.

- Biosensor design: Antibody engineering platform for NP functionalization, targeted delivery, etc. The antibody & engineering division is specialized in monoclonal antibodies, nanobodies and humanization. The state-of-the-art methodologies that are currently being carried out the most on our division are: i) obtaining and characterization of specific mouse monoclonal antibodies against proteins, viruses, bacteria and aptens; ii) Production and purification of antibodies and recombinant proteins both form bacteria and mammalian cells; iii) Design and generation of humanized antibodies, biosimilars, ADC and fragments: VHH, scFv, Fab.

- Stability tests and release studies (stability, aggregation studies, temperature, light, pH, final formula composition…)

- Local tolerance, pharmacokinetics and efficacy and adsorption studies (in vitro, in vivo toxicity studies, in-depth ADME-tox and biokinetics studies, in-depth barrier studies assessment – skin, intestine, Brain-Blood Barrier). Wide range of efficacy studies (in vitro and in vivo studies in mice/rats and large animals).

- Scale-up evaluation

Our Division is currently involved in numerous projects both in the national and international scale. The most relevant ones are:
- AMI (Euronanomed III-ERA-NET): Antidrug-antibody and drug Molecular detection in Inflammatory diseases with organic electronics platform.
- GLAM (H2020): Glass-Laser Multiplexed Biosensor for genitourinary cancer diagnosis.
- HYPOSENS (H2020): Nano-confined photonic system for detection of breast cancer spread to the lymph nodes.
- GRACIOUS (H2020): Grouping, Read-Across, CharacterIsation and classificatiOn framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
- NANOCOMMONS (H2020): The European Nanotechnology Community Informatics Platform: Bridging data and disciplinary gaps for industry and regulators (NanoCommons)


Offer
Partner Role:
Partner
Topic of the offer:
Development and characterization of novel molecules for imaging and therapy of tumors.
In vivo Imaging of early drug tumor response and drug resistance.
Pre-clinical studies for personalized therapy in cancer
Other information:
  • First name, Surname: Antonella Zannetti
  • Institution/organisation: Institute of Biostructures and Bioimaging-IBB /National Research Council-CNR
  • Country: Italia
  • E-mail: antonella.zannetti@cnr.it
  • Website: http://www.ibb.cnr.it/
Competences offered:
2D and 3D in vitro cancer cell models and patient derived organoid. Molecular imaging of tumor animal models including Patient derived xenografts using microPET/CT, microMRI (9.4T), fluorescence molecular tomography.
Offer
Partner Role:
Partner
Topic of the offer:
Imaging and Diagnostics, Targeted delivery systems, Regenerative Medicine
Other information:
  • First name, Surname: Pedro Ramos-Cabrer
  • Institution/organisation: CIC biomaGUNE
  • Country: Spain
  • E-mail: pramos@cicbiomagune.es
  • Website: http://www.cicbiomagune.es
Competences offered:
- Margnetic resonance imaging (preclinical 7 T and 11.7 T horizontal magnets for rodent studies) in a SPF animal facility, with AAALAC certification.
- Anatomical, Functional (including fMRI and DTI) and molecular imaging, on animal models of disease.
- Multiple pathologies (particular expertise on the CNS)
- Development and in vivo uses of multimodal imaging probes and contrast agents (we also have PET, SPECT and optical imaging equipment in our facilities)
- Development and in vivo uses of drug delivery systems
(our center has facilities, equipment and expertise for the development of all sort of biomaterials).

Offer
Partner Role:
Partner
Topic of the offer:
The Costa del Sol Hospital in the south of Spain is searching a consortium to join within the current open call. Our proffesionals are Medical Doctors in different fields and we can carry out studies envolving patients.
Other information:
  • First name, Surname: Elena Martin
  • Institution/organisation: Hospital Costa del Sol
  • Country: Spain
  • E-mail: elena.martin@hcs.es
  • Website: https://hcs.es
Competences offered:
The Agencia Sanitaria/Hospital Costa del Sol (Costa del Sol Hospital) is an autonomous body attached to the Ministry of Health of the Government of Andalusia in the South of Spain (Costa del Sol, Malaga). Its mission is to provide public quality health care to the citizens, seeking efficiency and optimum use of resources. The Costa del Sol Hospital has a network of 3 integrated care services distributed throughout the Costa del Sol territory (Marbellla, Mijas and Benalmadena) including 1.720 employees and covering a population of over 470.000 .We can provide collaboration in the development of study with patients.

Offer
Partner Role:
Partner
Topic of the offer:
The major research interests of the Lipidomics department are:
• Lipid metabolism in atherogenesis, diabetes and obesity (dyslipidemia markers): cellular and molecular biology of lipoproteins (Lp), dysfunctional HDL, dysregulation of entero-hepatic lipid metabolism (non-alcoholic fatty liver disease – NAFLD), Lp transport across the vascular endothelium (transcytosis process), cellular cholesterol efflux.
• Cellular and biochemical alterations in atherogenesis, diabetes and obesity: heart and cardiac valves, oxidized lipids, pro- and antioxidant enzymes associated with Lp, inflammatory mediators, experimental animal models and cardiovascular disease patients (CVD).
• Epigenetic markers in CVD and NAFLD: circulating and tissue-specific non-coding RNAs (miRNAs), enzymes for DNA methylation and acetylation.
• Genetic mechanisms of atherosclerosis: functional analysis of miRNAs, identification and validation of specific miRNAs target genes, gene polymorphisms.
Other information:
  • First name, Surname: Sima Anca
  • Institution/organisation: Institute of Cellular Biology and Pathology "N. Simionescu"
  • Country: Romania
  • E-mail: anca.sima@icbp.ro
  • Website: www.icbp.ro
Competences offered:
Technical expertise:
• in vivo experimental models for study of cardiovascular diseases and diabetes: diet-induced hyperlipidemic-hyperglycemic hamster, apoE/LDLR KO mice, echocardiography, in vivo imaging (IVIS);
• molecular biology techniques: mRNA/miRNA expression in blood/cells/tissues by PCR, microarray assay, real-time PCR, genotyping by PCR-RFLP technique; cloning (3’UTR plasmids);
• chromatographic techniques: FPLC, UHPLC, GC-MS;
• bioinformatics: functional ncRNA (miRNA) analysis;
• biostatistics and advanced modelling analysis;
• ultracentrifugation (separation and characterization of lipoproteins);
• flow cytometry analysis of circulating endothelial progenitor cells (EPC) and monocytes;
• immunological techniques: Elisa, Western blot, immunohistochemistry (confocal microscopy);
• enzymes activity (matrix metalloproteases, paraoxonase 1, phospholipase A2, cholesteryl ester transfer protein, myeloperoxidase, lipoprotein lipases).
Offer
Partner Role:
Partner
Topic of the offer:
Therapeutic delivery
Other information:
Competences offered:
in vivo testing in murine cancer (solid tumor and metastatic) animal models, cell biology, molecular biology, biochemistry, in vitro testing, etc
Offer
Partner Role:
Partner
Topic of the offer:
We a looking to join a project, relevant to Targeted delivery systems, polyelectrolytes, polyelectrolyte gels and network, layer-by-layer polyelectrolyte multilayered films.
Other information:
Competences offered:
I have experience in preparation and characterization of polyelectrolyte multilayered films used as drug delivery systems for buccal administration; investigation of barrier, mechanical and thermal properties of soft condensed matter, investigation of drug release kinetics, formulation of micro/nano-sized polyelectrolyte complexes.