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Type: Search

Search
Partner Role:
Partner
Topic of the idea:
Targeted Delivery systems
Other information:
Description of project idea:
The bioactive sequence (VPGVG)x in elastin protein can self assemble into alpha helices and using recombinant DNA technology elastin-like-polypeptides(ELP) with desired lengths can be produced towards building self assembled nanoparticles towards targeted delivery of drugs. We have expertise in recombinant production of ELP with precise length and chemical modification. We are looking for partners to utilize these particles for drug delivery.
Already involved partners, if any (roles/competences):

no partners yet

Partners sought (roles/competences):
We are looking for partners from industry and medical practitioners to develop a team towards drug delivery or multicomponent drug delivery.
Search
Partner Role:
Partner
Topic of the idea:
Targeted delivery systems
Other information:
  • First name, Surname: Maciej Serda
  • Institution/organisation: University of Silesia
  • Country: Poland
  • E-mail: maciej.serda@us.edu.pl
  • Website: www.us.edu.pl
Description of project idea:
The main goal of the project is to develop fullerene-gold nanorod hybrids for multi-functional treatment of triple negative breast cancer. The fullerene component will be responsible for siRNA transfection, whereas gold nanorods will be used as photothermal component.
Already involved partners, if any (roles/competences):
Dr Maciej Serda- (Poland), synthesis of fullerene derivatives Dr Martyna Krzykawska-Serda (Poland), in vitro and in vivo studies Dr Claudia Corbo (Italy), targeting proteins/protein corona analysis X- private company (Poland)- Electron Paramagnetic Resonanse imaging of tumor physiology, which includes tumor oxygenation and analysis of redox states
Partners sought (roles/competences):
We are looking for clinical/university partner with the strong background in breast cancer studies. His/Her role in the project will be preparation of patient-derived cancer cell lines or organoids.
Search
Partner Role:
Coordinator
Topic of the idea:
We propose to identify tumor-derived exosomal biomarkers isolated from plasma samples as potential biomarkers in non-small cell lung cancer (NSCLC). Competences offered: We have been experienced in isolation of exosomes, purification of microRNAs, cDNA preparation and microRNA profiling in various cancer tissue and liquid biopsies.
Other information:
  • First name, Surname: Nihat Dilsiz
  • Institution/organisation: Istanbul Medeniyet University
  • Country: Türkiye
  • E-mail: nihat.dilsiz@medeniyet.edu.tr
  • Website: medeniyet.edu.tr
Description of project idea:
Exosomes are biological nanoparticles with an average diameter of between 30 and 100 nm in size and produced by almost all cell types in the human body. They are released into all body fluids contain DNA, RNA species and specific protein biomarkers that are important as cancer biomarkers and therapeutic targets. These bioactive molecules are transferred from donor cells to target cells by exosome transport system, leading to reprogramming of the recipient cells. Therefore, the specific exosomes secreted by tumor cells that contain the biomarkers can be used to predict the existence of a tumor in cancer patients. Due to their small size, natural products of the body cells, non-toxic characteristics and crossing the various biological barriers, they are an excellent delivery system for anti-tumor miRNAs and anti-tumor drugs in therapeutic tools. Tumor-derived exosomal miRNA research is highly dynamic and promises novel approaches in cancer prevention, early detection, diagnosis and personalized therapy. The new and highly sensitive detection method liquid biopsy based exosome analysis provides a promising platform for early diagnosis, therapeutic and prognostic process about a disease rather than the conventional tissue biopsy. Liquid biopsy, a new star of cancer detection, is growing in popularity because of their minimal invasiveness, ease of use, painless, lower sample volume, lower cost, more accuracy and high throughput for personalized cancer therapy. It is important to know that most cancers can be more effectively treated if they are discovered in early stages. In planned project, the potential of 10 miRNAs, which have an active role in lung cancer will be determined by comparing the amount of exosomal miRNAs to be isolated from blood samples of healty individuals and patients with lung cancer, as personalized exosomal biomarkers.
Already involved partners, if any (roles/competences):
None
Partners sought (roles/competences):
We expect: Partners to have experiences with microRNA profiling and droplet digital PCR techniques for quantification of microRNA in exosomes.
Search
Partner Role:
Coordinator
Topic of the idea:
Light curable resin-based composite (RBC) materials
Other information:
  • First name, Surname: Ecem Özdemir
  • Institution/organisation: Etkin Proje
  • Country: Türkiye
  • E-mail: ecem.ozdemir@etkinproje.com
  • Website: https://www.etkinproje.com/
Description of project idea:
Light curable resin-based composite (RBC) materials have continously evolved ever since introduction into dental field in 1970s. These complex materials consist of inorganic and organic filler particles embedded in an organic, resin-based matrix. RBCs are typically composed of four (4) major components which are resin matrix, inorganic fillers, coupling agents, and the initiator/accelerator system. Organic polymer matrix consists of methacrylate monomers such as bisphenol-A-glycerolate dimethacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), urethane dimethacrylate (UDMA), bisphenol A ethoxylated dimethacrylate (bis-EMA), etc. In general, the physical and mechanical properties of the composite are improved in direct relation with the filler added. While the types of fillers are varied, most consist of silica (SiO2), zirconia (ZrO2), and titania (TiO2) in form of micro/nanoparticles or whiskers. Moreover, single-walled carbon nanotubes (SWCNTs), hydroxyapatite nanorods, and glass fibers as a fiber fillers have been used as reinforcing agent. In dental composites, among all shapes, mostly fillers with particle shape, in size of micro/nanometer, are used. Composite materials are meet physical and mechanical expectations in a period of a time. However, the main reasons of the failure of the restorations are still comes from mechanical fatigue degradation and secondary caries. To overcome the mechanical degredation nanocrystalline cellulose (NCC) addition could be a good alternative.
Nanocrystalline cellulose are unique nanomaterials derived from the most abundant and almost inexhaustible natural polymer, cellulose. These nanomaterials have received significant interest due to their mechanical, optical, chemical, rheological and biocompatible properties. In fact, the axial Young’s modulus of a NCC is theoretically stronger than steel and similar to that of Kevlar. For NCCs, the theoretical value of Young’s modulus for the native cellulose perfect crystal has been estimated to be 167.5 GPa. Recently, the Raman spectroscopy technique was utilized to measure the elastic modulus of native cellulose crystals from tunicate and cotton to yield values of 143 GPa and 105 GPa, respectively. As a result of their distinctive properties, nanocrystalline cellulose has the potential of becoming an important class of renewable nanomaterials, which could find many useful applications. The main application of NCC is for the reinforcement of polymeric matrix in nanocomposite materials. Favier et al. (1995) was the first to report the use of NCC as reinforcing fillers in poly(styreneco-butyl acrylate) (poly(S-co-BuA))-based nanocomposites. Since then, numerous nanocomposite materials were developed by incorporating NCC into a wide range of polymeric matrices. The properties of these cellulosic nanocomposites depend on the types and characteristics of NCC and polymeric matrices (which could be both natural and synthetic polymers). Chemical functionalisation of NCC improves its dispersability in organic solvents and this greatly expands its potential applications in various sectors. Recent studies reported that NCC has good chemical properties (stability and resistance) and is becoming more and more available. As more researchers become interested in NCC, many applications in diverse fields have been proposed and explored, ranging from iridescent pigments to biomolecular NMR contrast agents. Over the years, costs went down, which could make NCC as a very interesting reinforcing agent for polymers. For example, a theoretical cost-performance analysis between polypropylene nanocomposites with NCC and single-wall carbon nanotube (SWCNT) showed that NCC is about 316 times cheaper with environmental advantages like biodegradability, renewability, and abundance. Considering the impact of NCCs on mechanical strength, the use of NCCs as a filler in RBCs can improve the strength of these materials and extend the service life of composite fillings.
Already involved partners, if any (roles/competences):

None

Partners sought (roles/competences):
We expect:

Partner 1 to do - Coloring of NCC loaded RBCs according to vita color scale and
- Determination of radioopacity properties of NCC loaded RBCs

Partner 2 to do - Evaluation of biocompatibility properties of NCC loaded RBCs according to
ISO 10993 standards
- Investigation of antibacterial properties of NCC loaded RBCs

Partner 3 to do - Development of novel organic matrix components to reduce polymerization
Shrinkage of NCC loaded RBCs
Search
Partner Role:
Coordinator
Topic of the idea:
Viral inhibition properties of oligosaccharide based nanoparticles targeted with antiHbs surface antigen receptor binding ligand depleting host cell membrane cholesterol for Hepatitis B infection and HBV induced liver cancer
Other information:
  • First name, Surname: Erem Bilensoy
  • Institution/organisation: Hacettepe University Faculty of Pharmacy
  • Country: Turkey
  • E-mail: ebilensoy@gmail.com
  • Website: www.erembilensoy.com
Description of project idea:
Viral inhibition properties of oligosaccharide based nanoparticles targeted with antiHbs surface antigen receptor binding ligand depleting host cell membrane cholesterol for Hepatitis B infection and HBV induced liver cancer
Already involved partners, if any (roles/competences):
Hacettepe University TUBITAK MAM GMBE University of Sevilla Carol Davila University of Medicine and Pharmacy
Partners sought (roles/competences):
Partners (SME or clinic/hospital preferably) with experience on viral inhibition and virus entry assays are welcome
Search
Partner Role:
Partner
Topic of the idea:
Our goal is fabrication, characterization, and application of new targeted drug delivery systems for the treatment of various cancers.
Other information:
Description of project idea:
Drug delivery systems (DDSs) have emerged as a way of improving drug efficiency. Most chemotherapeutics have their own drawbacks, simply because drugs cannot stay long enough in the body fluid as well as they cannot reach to the targeted section of the body with the desired drug concentration. Therefore, it is highly important to develop DDSs which will promote the desired drug release profile while minimizing the undesired consequences.
Already involved partners, if any (roles/competences):
Not yet
Partners sought (roles/competences):
We are looking for collaborators to do more detailed work, especially for the understanding of delivery systems mechanisms in vivo.
Search
Partner Role:
Partner
Topic of the idea:
We want to test pharmacological inhibition of the histone methyltransferases SUV420H1/2 in brown adipose tissue (BAT) for treating T2D.
Other information:
  • First name, Surname: Simona Pedrotti
  • Institution/organisation: Ospedale San Raffaele, Milan
  • Country: Italy
  • E-mail: pedrotti.simona@hsr.it
  • Website: www.hsr.it
Description of project idea:
We have recently demonstrated that pharmacological inhibition of Suv420h epigenetic activity is sufficient to activate PPAR-γ and increase metabolic activity in a PPAR-γ-dependent manner, providing the first epidrug able to activate BAT metabolic activity (doi: 10.1126/sciadv.aav1472). Here, we propose to use a pre-clinical mouse model of T2D to test genetic and pharmacological SUV420H1/H2 inhibition and elucidate associated pathways.
To evaluate pharmacological inhibition of Suv4-20h, we will use a pre-clinical mouse model of T2D. As a general strategy, interscapular BAT of db/db mice will be injected with
appropriate carrier structures containing Suv420h inhibitor/siRNAs or vehicle. The overarching framework of these activities is the modulation of both pharmacokinetics and
pharmacodynamics of active principles, addressing them to the locations and with the timing that
maximize their efficacy while minimizing off-target effects. Experimental animals will be evaluated for various phenotypes relevant for diabetes.
Already involved partners, if any (roles/competences):

None

Partners sought (roles/competences):
We are looking for research groups and/or companies available for developing gel/microparticles containing the SUV420H1/H2 pharmacological inhibitor A196 or SUV420H1/H2-specific siRNAs. We are seeking leading expert in materials for targeted and/or biologically responsive drug delivery, with expertise in polymer synthesis, colloidal characterization and cell-material interactions.
Search
Partner Role:
Partner
Topic of the idea:
Our goal is to realize early diagnosis of cancer, personalized medicine and successful drug discovery using physiologically relevant microenvironments enabled by lab-on-a-chip devices optimized for 3D cell culture. We are looking for collaborators (i) who can provide liquid biopsy samples from cancer patients and/or animal models (ii) who would like to test novel drugs or drug delivery platforms.
Other information:
  • First name, Surname: Devrim Pesen Okvur
  • Institution/organisation: Izmir Institute of Technology
  • Country: Turkey
  • E-mail: dpesenokvur@gmail.com
  • Website: https://mbg.iyte.edu.tr/en/home-page/
Description of project idea:
We develop and fabricate lab-on-a-chip (LOC) devices for 3D cell culture. LOC enable us to mimic the microenvironment of cells and thus in vivo conditions. We investigate invasion and extravasation of cancer cells under various settings with and without drugs using confocal microscopy followed by quantitative image analysis. Our goal is to develop LOC and associated methods to realize early diagnosis of cancer, personalized medicine and successful drug discovery.
Already involved partners, if any (roles/competences):
Initio Cell Ltd is our spin-off company located in UK. initiocell.com
Partners sought (roles/competences):
(i) who can provide liquid biopsy samples from cancer patients and/or animal models (ii) who would like to test novel drugs or drug delivery platforms.
Search
Partner Role:
Partner
Topic of the idea:
Our idea aims to develop new formulations of biomaterials composed of biomolecules, borate and phosphate groups for new generation borophosphate glasses that possess the potential of “boroapatite formation via biodegradation” for orthopedic applications.
Other information:
Description of project idea:
Organic-mediated borophosphate glasses have not been adequately investigated and are still debatable. In this study, we will search for the preparation of these glasses Detailed parametrization experiments will be performed to obtain materials with desired properties for orthopedic applications.

Already involved partners, if any (roles/competences):

-

Partners sought (roles/competences):
We are willing to join a consortium and we can contribute to this call by materials synthesis & characterization and preliminary bioactivity tests.
Cell culture tests for biocompatibility and biodegradability properties can be performed by others partners.
Search
Partner Role:
Coordinator
Topic of the idea:
Natural anti-cholinesterase enzyme inhibitors and in vivo tests. However, I am interested in research on the anti-cancer activities of new natural compounds.
Other information:
Description of project idea:
We would like to conduct in vivo trials of anti-cholinesterase enzyme inhibitors from Liquidambar Orientalis. To date, we have found that some compounds and fractions isolated from Liquidambar Orientalis drugs show very high anticholinesterase enzyme activity in vitro. We wish to test the anticholinesterase activity of these compounds and some fractions in vivo with various nanoparticles. In addition, it is another objective to test the activity of some compounds and fractions obtained from Liquidambar Orientalis resin and its fruits against Stomach and colon cancer cell lines in vivo tests. We would like to make in vivo applications of fraction and bioactive compounds that we have high activity in in vitro conditions as silver or gold nanoparticles.
Already involved partners, if any (roles/competences):

we have no partners yet.

Partners sought (roles/competences):
We are looking for partners who can contribute to our project idea. We are looking for partners who can do in vivo tests.
Search
Partner Role:
Partner
Topic of the idea:
Biocompatible monodispersed nanohydrogel with a range sizes of 20 to 500 nm for loading and delivering drugs. The system can be targeted to tumor using specific peptides and labelled with NIR probes
Other information:
Description of project idea:
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Already involved partners, if any (roles/competences):

ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Partners sought (roles/competences):
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Type: Offer

Offer
Partner Role:
Partner
Topic of the offer:
Lung Tumor Immunology group
Other information:
  • First name, Surname: Savvas Petanidis
  • Institution/organisation: Aristotle University of Thessaloniki, Department of Medicine
  • Country: Greece
  • E-mail: spetanid@auth.gr
  • Website: www.med.auth.gr
Competences offered:
Molecular Profiling of lung cancer tumor saples, miR analysis, BALBc mice, Ex vivo tissue culture
Offer
Partner Role:
Partner
Topic of the offer:
I am a Pharmaceutical Toxicologist. My past exprience focused on reproductive toxicology. Recently we are working on biological effects of novel synthesized photodynamic therapy agents (i), and working on establishing a GLP toxicology research laboratory that will include tests for oral toxicity (acute, sub-acute and chronic toxicity tests) and genotoxicity (Ames, in vivo chromosomal aberration and in vitro micronucleus tests) according to OECD guidelines (ii).
Other information:
Competences offered:
Toxicity testing, Toxicity risk assesment
Offer
Partner Role:
Partner
Topic of the offer:
Our goal is synthesis, characterization, and application of new targeted magnetit nanoparticles delivery systems for the treatment of various cancers.
Other information:
  • First name, Surname: Mediha Suleymanoglu
  • Institution/organisation: Istanbul University, Faculty of Medicine, Medical Biology
  • Country: Turkey
  • E-mail: mediha.suleymanoglu@istanbul.edu.tr
  • Website: https://www.istanbul.edu.tr
Competences offered:
We have extensive experience in vitro and in vivo experiments especially cell culture, tumor mouse models.
Synthesis of magnetit nanomaterials
Loading with anti-cancer drugs
Targeting of the nanoparticle to the tumour cells
Offer
Partner Role:
Partner
Topic of the offer:
UMR 1240 INSERM, Clermont Auvergne University, attached to the ITMO "Technologies for Health" and the CLARA Cancer Research Cluster, has as its main objectives the updating and clinical transfer of new tools and/or targets for treatment and therapeutic monitoring, mainly in oncology. This unit, created in 2017, is the result of the merger of the UMR 990 INSERM (Molecular Imaging and Vector Therapy) and the ERTICA team (Research Team on Individualized Cancer Treatment). The unit's strategy is based on the development of molecular vectors that selectively address active ingredients with diagnostic and therapeutic activity towards a molecular, cellular or tissue target or a signalling pathway. The radiolabeling of these vectors opens up promising fields of application for internal radiotherapy (IRT) and/or scintigraphic imaging. The use of these same vector structures to selectively address a non-radioactive active ingredient (e.g. targeted therapies, nano-objects, etc.) to these same targets is also being evaluated. In this context and based on its strong expertise in radiolabeling and the study of response and/or resistance biomarkers, the unit is organized around two teams whose projects are interconnected: research "from bench to bed" and "from bed to bench" is focused on melanoma, chondrosarcoma and triple negative breast cancer (TNBC). Following preclinical validation by team 1 of the theranostic strategies envisaged, clinical transfer is handled by team 2, notably by exploiting dedicated resources such as the Centre d'Innovation et de Recherche en Médecine Nucléaire (CIRMEN). In return, the identification of biomarkers of response and/or resistance to treatment will be carried out during prospective and retrospective studies in order to identify new targets and validate relevant therapeutic options. New targets/vectors will be developed for internal radiotherapy, as well as pre-targeting strategies for radioimmunotherapy. The development of novel radiolabels and/or those that can be exploited in PET imaging will be widely promoted.
Other information:
  • First name, Surname: Emmanuel Moreau
  • Institution/organisation: UMR Inserm/Clermont-Arvergne University
  • Country: France
  • E-mail: emmanuel.moreau@uca.fr
  • Website: https://imost.uca.fr
Competences offered:
organic chemistry, medicinal chemistry; radiochemistry (fluorine-18; gallium-68; copper-64; indium-111; lutecium-177), in vitro biology; in vivo imaging (TEP, TEMP, fluorescence) cancer cartilage pathologies
Offer
Partner Role:
Coordinator
Topic of the offer:
We are searching for a coordinator or for a partner Topic: Regenerative Medicine
Other information:
Competences offered:
We have developed nanoparticles that elicit regeneration pathways when administered to rats, which suffer from Multiple Organ Dysfunction Syndrome caused by severe sepsis. We are interested in partner/s who have an animal model for testing our innovative nanoparticles in regenerative medicine. In addition, we are interested in partners who could participate in the development of the said NCs by GMP and any other expertise that will enable the project to reach clinical trials.
Offer
Partner Role:
Partner
Topic of the offer:
Development of new functional nanomaterials for their application in biosensors, drug delivery and bioimaging. Our expertise is on the synthesis of Au, Ag, and Quantum dot nanoparticles with various surface functionalities. We have a very enthusiastic group that works on the synthesis of this materials and their biological applications.
Other information:
Competences offered:
Synthesis of nanomaterials
Fluorescence based biosensors and bioimaging
Mass spectrometric characterization and bioimaging
Offer
Partner Role:
Partner
Topic of the offer:
Polysaccharide AEROGELS for targeted drug delivery.
Other information:
  • First name, Surname: Can Erkey
  • Institution/organisation: Koc University
  • Country: Turkey
  • E-mail: cerkey@ku.edu.tr
  • Website: http://mysite.ku.edu.tr/cerkey/
Competences offered:
1. Aerogel synthesis 2. Aerogel drug loading 3. Aerogel characterization 4. Aerogel coating
Offer
Partner Role:
Partner
Topic of the offer:
Field of interest 1: Development of diagnostic tools based on electrochemical or optical nanobiosensors to be applied as on-site point-of-care devices. Field of interest 2: Development of biomaterials for 3D printing (FDM, SLA) for biomedical applications (scaffolds, stents…)
Other information:
  • First name, Surname: Paula Ciaurriz
  • Institution/organisation: Naitec
  • Country: España
  • E-mail: pciaurriz@naitec.es
  • Website: www.naitec.es
Competences offered:
- Selection of suitable biosensor technology according to target analyte, bioreceptor, end-user needs… - Surface functionalization - Development and validation of assay protocol for target analyte measurement (matrix effect assesment, multi-analyte detection, signal amplification with nanoparticles…) - Design and fabrication of optical transducers based on gold &SiO2 & Si3N4 & other periodic nanostructures - Design and fabrication of printed electrochemical transducers - Clean room facilities for nanostructure fabrication by Laser Interference lithography (Llyoid's mirror, SEM, e-beam evaporator, NIL...) - Different functional Printing technologies: Ink-jet, flexografy, screen and offset printng, Laser Induced Forward Transfer (LIFT) - Development of hybrid materials (filaments, pellets and resins) with added properties based on particles addition & polymers mixing - Design and fabrication of 3D models by Stereolithography and Fused Deposition Modelling technologies - Mechanical characterization of 3D printed models
Offer
Partner Role:
Coordinator
Topic of the offer:
Colorectal cancer is the most frequently diagnosed type of cancer in the world. The therapeutic index of drugs used in cancer is low. Undesirable side effects and toxic effects may occur when the therapeutic dose is exceeded. Cancer drugs, kill both cancerous cells and healthy cells is the another reason for failure in treatment. To eliminate or minimize the negativities observed in conventional therapy, to increase transport to cellular levels, to increase the concentration of drugs in the circulation, to optimize release kinetics, to change pharmacokinetic and pharmacodynamic properties of drugs, to provide effective and safe doses at low or high doses, and most importantly to controlled release systems are targeted to achieve the desired level of therapeutic response at the target site without causing any undesirable effects in the regions. Capecitabine is an anti-neoplastic prodrug used in monotherapy or combination therapy in colorectal cancers. The thymidine phosphorylase enzyme, which mediates the final stage of the capecitabine activation pathway, is expressed in the tumor tissues in higher amounts than in healthy tissues. This makes the capecitabine drug more tumor-specific than other chemotherapeutic agents. Studies have shown that non-steroidal anti-inflammatory drugs reduce the risk of colorectal cancer by 40-60%.Meloxicam is a semi-selective non-steroidal anti-inflammatory drug derived from enolic acid. The aim of this project is to investigate the efficacy of folic acid conjugated capecitabine containing chitosan nanoparticles and meloxicam, in both in vitro conditions and in the experimental colon cancer model.
Other information:
Competences offered:
Colorectal cancer, Nanoparticle, Targeted drug delivery, Capecitabine, Meloxicam,Pharmacology and Therapeutics
Offer
Partner Role:
Partner
Topic of the offer:
Diagnostics
Other information:
  • First name, Surname: Roberto de la Rica
  • Institution/organisation: Health Research Institute of the Balearic Islands (IdISBa)
  • Country: Spain
  • E-mail: roberto.delarica@ssib.es
  • Website: http://www.delaricalab.com/
Competences offered:
We develop immunosensors made of paper that incorporate plasmonic nanoparticles as probes. The immunosensors can be tailored to detect a wide variety of targets, including biomarkers and pathogens, in biological matrices such as urine and blood. Colorimetric detection with smartphone apps developed in our lab. Focus on infectious diseases, sepsis and personalisation of antimicrobial treatment with our rapid diagnostic tests. Multidisciplinary group including physicians, chemists, biologists and bioengineers. Access to patient samples. Possibility of doing translational studies in ICU in Spain.
Offer
Partner Role:
Partner
Topic of the offer:
Aptus Biotech is a biotech start-up founded in 2010 from a collaboration agreement with the Ramon y Cajal Hospital Foundation (FIBio-HRC). Our goal is to become a leading start-up in the development of new biotechnological applications based on aptamers. APTUS activities are focused on: Aptamer selection services. Supply of customized aptamers for different biotechnological applications. R&D projects in collaboration with other research centers and companies, where aptamers provide a competitive advantage.
Other information:
  • First name, Surname: Miguel Moreno
  • Institution/organisation: Aptus Biotech
  • Country: Spain
  • E-mail: miguel.moreno@aptusbiotech.com
  • Website: http://en.aptusbiotech.com/
Competences offered:
Our R&D activities are focused in developing and implementing specific biotechnological applications, where the aptamer technology brings an added value. The R & D of Aptus is based on high quality science and technology supported by reference research centers, especially in the Laboratory of Aptamers of the IRYCIS. We seek to develop innovative applications that add value to the end user market. We collaborate with companies and market operators to provide useful and cost effective solutions using the aptamer technology. I+D+I Seeking for new applications: Drug discovery. Drug optimization and vehiculization. Diagnostics Aptasensors (Biosensors) Other? If you have a proposal, please Email us. miguel.moreno@aptusbiotech.com
Offer
Partner Role:
Partner
Topic of the offer:
Short peptides are ideal candidate ligands exhibiting a broad spectrum of advantageous properties (biocompatibility, facile and cheap synthesis, structural modifications, simple chemistry and high affinity). By computational (virtual) analyses, peptides design can be inspired by natural interactions to provide a plethora of candidates for further affinity refinements. Such peptides can serve as promising targeting ligands for active delivery of virtually any nanoscaled delivery system. Therefore, we are looking for partners that are searching for novel targeting peptide-based ligands whose design will be based on their demands (targeted cell type, conjugation chemistry, etc.).
Other information:
  • First name, Surname: Zbynek Heger
  • Institution/organisation: Mendel University in Brno
  • Country: Czech Republic
  • E-mail: heger@mendelu.cz
  • Website: https://ucb.af.mendelu.cz/
Competences offered:
We use high-throughput computational analyses (docking, MD, MM, QM) to develop novel peptides based on homo- or hetero-oligomerization of receptors or their interactions with natural ligands. We offer: - expertise in in silico design of targeting/homing peptides + high yields synthesis - in silico and wet lab determination of peptides structure and stability - conjugation chemistry for peptides immobilization on delivery vehicles - in vitro (cell cultures) tests of peptides functionality (affinity, biocompatibility, etc.)
Offer
Partner Role:
Partner
Topic of the offer:
Description of project idea: Our idea is to obtain high-performance, multifunctional coatings with antibacterial properties deposited by advanced PVD techniques for different applications (i.e. orthopaedic or dental implants, medical instrumentation) with surface modifications in order to have good biocompatibility and low cytotoxicity with the surrounded tissues. The proposed coatings will be used for preventing the bacterial colonization of biomedical surfaces by their composition and also by surface functionalization. Already involved partners, if any (roles/competences): None. Partners sought (roles/competences): We can contribute to this call by materials synthesis, surface modification and characterization. We are looking for research groups and/or companies/ clinic/hospital available who have experience in corrosion evaluation in more detail, evaluation of biocompatibility and investigation of antibacterial properties of the obtained materials, for understanding the mechanisms in vitro and in vivo.
Other information:
  • First name, Surname: Mihaela Dinu
  • Institution/organisation: National Institute for Optoelectronics- ReCAST Center
  • Country: Romania
  • E-mail: mihaela.dinu@inoe.ro
  • Website: www.recast.inoe.ro
Competences offered:
We can provide a series of deposition and characterization techniques (SEM, EDS, AFM, XRD, surface profilometer, thickness, nano-indentation, adhesion, tribological properties, degree of wetting, chemical bonds). For more information, see http://recast.inoe.ro/research_facilities.html.
Offer
Partner Role:
Partner
Topic of the offer:
We focus on the development of targeted nanoparticle carriers for gene therapy or modulation of RNA expression in mammary cells. Our models cover immune disorder like diabetes as well as cancer environment (breast and colon). We would like to expand our research for new applications for example in neurodegenerative diseases/brain tumors (we have good experience with adult neuronal cultures ex vivo!).
Other information:
Competences offered:
Molecular biology techniques, strong background in work with RNA, micRNA and proteins, including arrays. Cell transfections. Cellular assays like proliferation, invasion, migration, apoptosis etc. Primary, 2D, and 3D cultures. Microscopy and flow cytometry analysis of surface/intracellular antigens. In vivo models - licence and basic models experience.
Offer
Partner Role:
Partner
Topic of the offer:
- Field of interest 1: Development of diagnostic tools based on electrochemical or optical nanobiosensors to be applied as on-site point-of-care devices. - Field of interest 2: Development of biomaterials for 3D printing (FDM, SLA) for biomedical applications (scaffolds, stents…)
Other information:
  • First name, Surname: Paula Ciaurriz
  • Institution/organisation: Naitec
  • Country: España
  • E-mail: pciaurriz@naitec.es
  • Website: www.naitec.es
Competences offered:
- Selection of suitable biosensor technology according to target analyte, bioreceptor, end-user needs… - Surface functionalization - Development and validation of assay protocol for target analyte measurement (matrix effect assessment, multi-analyte detection, signal amplification with nanoparticles…) - Design and fabrication of optical transducers based on gold &SiO2 & Si3N4 & other periodic nanostructures Design and fabrication of printed electrochemical transducers - Development of hybrid materials (filaments, pellets and resins) with added properties based on particles addition & polymers mixing - Design and fabrication of 3D models by Stereolithography and Fused Deposition Modelling technologies - Mechanical characterization of 3D printed models
Offer
Partner Role:
Partner
Topic of the offer:
Our group has a clinical background and is specialized in the field of rheumatological disorders, with a particular focus in osteoarthritis. In this area, we are interested in developing methods based on protein analysis to facilitate regenerative medicine strategies for osteoarticular tissues.
Other information:
  • First name, Surname: Cristina Ruiz-Romero
  • Institution/organisation: INIBIC-Hospital Universitario A Coruña
  • Country: Spain
  • E-mail: cristina.ruiz.romero@sergas.es
  • Website: http://girblanco.com
Competences offered:
We have extensive experience in the proteomic analysis of joint-related tissues, biofluids and cells, including mesenchymal stromal cells undergoing chondrogenesis. To this aim, we employ different LC-MS/MS or immunoaffinity-based proteomics technologies.
Offer
Partner Role:
Partner
Topic of the offer:
Our team is investigating the pathogenesis of common ocular diseases. In particular, we are focused on eye pathologies due to diabetes. We are serious about our work and are looking for new, precision, and non-invasive treatment strategies to treat these types of ocular diseases. The following projects are carried out by our group: a) Development of targeted new generation Nanobiotherapeutics for the treatment of Diabetic Macular Edema (DME). b) Synthesis and characterization of Controled delivery systems for the treatment of uveitis.
Other information:
  • First name, Surname: Nagihan UGURLU
  • Institution/organisation: Ankara Yildirim Beyazit University
  • Country: Turkey
  • E-mail: drnagihanu@gmail.com
  • Website: https://aybu.edu.tr/
Competences offered:
We offer complete expertise in the fields of in-vivo (rabbits) and in-vitro testing. In the case of in-vivo testing, our laboratory equipped for examination of anterior and posterior segments. Handheld digital biomicroscope (Hawk Eye, Dioptrix, France), intraocular pressure (IOP) measurement (TONO-PEN AVIA® Tonometer, USA), scanning fluorophotometer (FM-2 Fluorotron™ Master, Ocumetrics, USA), color fundus photography (CFP) (Phoenix ICON™, Pleasanton, CA, USA), fundus fluorescein angiography (FFA) (Phoenix ICON™), and optical coherence tomography (OCT) (Bioptigen, Durham, NC, USA) devices are used for in-vivo trails (rabbits). Furthermore, Toxicology, pharmacodynamics and pharmacokinetics studies are conducted by our team.
Offer
Partner Role:
Coordinator
Topic of the offer:
In our project, we have partners for the production of nanoparticles, characterization an in vitro studies. We seek for partners to develop orthotopic tumor mouse models and in vivo imaging of our nanoparticles. Additionally, we look for partners which have confocal microscopy for in vitro experiments.
Other information:
Competences offered:
Our team consists of experts for the production and characterization of nanoparticles. Additionally, we have experienced development of drug resistant cancer cells and in vitro experiments. We only need partners for in vivo experiments especially orthotopic tumor mouse models and in vivo imaging.
Offer
Partner Role:
Partner
Topic of the offer:
Multidrug resistance (MDR) to chemotherapeutic agents is one of the major unsolved problems for the success of cancer chemotherapy. Therefore, a promising strategy to enhance the efficacy of classical chemotherapy is antagonization of resistance-mediating factors in order to restore drug sensitivity.
We address this issue by designing; fabricating; physicochemically characterizing and testing of, novel types of multifunctional nanoparticle formulations to orchestrate multiple functions simultaneously as a way of reversing MDR by means of nanomedicine.
Examples of publications:
(2019)International Journal of Pharmaceutics, 561:74–81
(2018)Journal of Pharmaceutical Sciences, 107:934–941
(2017)Colloids and Surfaces B: Biointerfaces, 156:175–185
(2017)Pharmaceutical Research, 34:175–184
(2016)Bioconjugate Chemistry, 27:1098–1111
Other information:
  • First name, Surname: Cenk Daglioglu
  • Institution/organisation: İzmir Institute of Technology
  • Country: Türkiye
  • E-mail: daglioglucenk@gmail.com
  • Website: www.iyte.edu.tr
Competences offered:
Rationally designing the bottom-up synthesis of multifunctional nanoparticle formulations with diagnostic and therapeutic capabilities and applications of these materials in nanomedicine to improve cancer care. We employ various tools and techniques in bioorganic chemistry, biochemistry, molecular and cell biology.

Looking for partners especially who have right to access in vivo models.
Offer
Partner Role:
Partner
Topic of the offer:
We develop 3D cell/tissue constructs utilizing nano-structures, either natural (i.e. exosomes) or synthetic (i.e. peptide amphiphiles) components, to be used in tissue engineering applications.
Other information:
Competences offered:
We are willing to join a consortium focusing on application of new-generation tissue engineering constructs in vivo. We currently do cell culture for various types of cell lines including multipotent and pluripotent stem cells in addition to skin cells, endothelial cells, cancer cells, cartilage and bone cells, neural cells. For in vitro characterisation, we apply cell proliferation, live/dead assay, cellular uptake, apoptosis assay, angiogenesis assay, cellular differentiation (immuncytochemistry, qPCR, and omics analysis). We are able use polymers for constructing enzyme-triggered, thermo-sensitive, or UV-responsive hydrogels for the purpose of use in 2D/3D tissue engineering applications. In addition, we are able to isolate natural nanovesicles (i.e. exosomes) from many types of biological fluids. Finally, we very currently have been focused on establishing organoid culture environment and probably will be ready to collaborate in this in the near future. We are seeking a consortium to work in a tight collaboration with research groups who can use our technologies and perform in vivo experiments to move them one step forward.
Offer
Partner Role:
Partner
Topic of the offer:
We are interested in “Diagnostics” or “Targeted Drug Delivery” topics of EuroNanoMed 3 call. In this context we offer synthesis and characterization of some compounds such as phthalocyanines, BODIPYs, coumarins and pyrenes etc. to be used for biosensor development or targeted drug delivery systems for photodynamic therapy (PDT).
Other information:
  • First name, Surname: Mahmut Durmus
  • Institution/organisation: Gebze Technical University
  • Country: Turkey
  • E-mail: durmus@gtu.edu.tr
  • Website: http://www.gtu.edu.tr/
Competences offered:
Durmus Research Group is an outstanding research group which has wide experience in synthesis and characterization of some compounds such as phthalocyanines, BODIPYs, coumarins and pyrenes etc. The Group has also wide experience of development of electrochemical and fluorescent biosensors and photodynamic therapy of cancer. We offer either synthesis and characterization of some compounds such as phthalocyanines, BODIPYs, coumarins and pyrenes etc. to be used for development of biosensors for point-of-care diagnostic systems or to be used as active molecules for targeted drug delivery systems for photodynamic therapy.
Offer
Partner Role:
Partner
Topic of the offer:
Izmir Institute of Technology, which is ranked the third best university in Turkey located in Izmir, and FYK Technology, an SME, which is specialized in machine learning applications also located in Izmir, are seeking partners for a project application to the EuroNanoMed III 2020 call under the areas: b) Diagnostics and/or c) Targeted delivery systems.
Other information:
  • First name, Surname: Tugkan Tuglular
  • Institution/organisation: Izmir Institute of Technology, MitoAI Research Group
  • Country: Turkey
  • E-mail: tugkantuglular@gmail.com
  • Website: https://iyte.edu.tr/
Competences offered:
Izmir Institute of Technology: MitoAI Research Group at Izmir Institute of Technology is a multidisciplinary research group led by Prof. Dr. Serdar Ozcelik (Dept. of Chemistry) and Assoc. Prof. Dr. Tugkan Tuglular (Dept. of Computer Engineering). A graduate member, Yalcin Tarkan from FYK Technology, of MitoAI Research Group is currently working on his M.Sc. thesis titled "Development of machine learning platform for analysis of mitochondrial features in live-cell images" in Izmir Institute of Technology, İzmir, Turkey. In this project, under the co-advisors Prof. Dr. Serdar Ozcelik and Assoc. Prof. Dr. Tugkan Tuglular, it is aimed to build a smart image-analysis platform to support and ease discoveries in fluorescent microscopic images of living cells to explore structural and behavioral effects on mitochondria in response to the various stimulations of -healthy and diseased- cells. Machine learning tools and techniques are to be employed to analyze time series images to enable researcher to assess mitochondrial features much faster and more precisely. Prof. Dr. Serdar Ozcelik: Serdar Ozcelik obtained BSc. and MSc. degrees in engineering physics at Ankara University, Turkey, in 1986 and 1988 respectively. While he was pursuing toward PhD degree in engineering physics, working on to develop methods to correct clinical artifacts on single photon emission computed tomography he was selected for NATO Science Scholarship to pursue PhD degree in USA. He earned his PhD degree in chemistry at City University of New York in 1996, developed mirror-less laser materials based on J-aggregates (a special group of light emitting molecules). He conducted research on receptor-receptor interactions at single molecule level at Pacific Northwest National Laboratory, WA, USA, from 2002 to 2004 as a visiting scientist. Recently, he received Fulbright scholarship to conduct a research on improved efficacy of radiotherapy using nucleus targeted gold nanoparticles at Stanford University, CA, USA. He is directing a funded research project related to photodynamic therapy on lung cancer utilizing mitochondria targeted drug-nanoparticle conjugates sensitized by red-light. Dr. Ozcelik is developing nanomaterials including colloidal quantum dots and methods to fabricate microdisplay using colloidal alloyed quantum dots (another funded research project). He focused on nanomedicine to develop new diagnostics and therapeutics at single cell level using house-made targeted nanoparticles. Dr. Ozcelik is a professor of chemistry at Izmir Institute of Technology (IYTE) where he served as Dean of Faculty of Science, 2011 - 2018. As dean, he established two totally new departments at IYTE: Department of Photonics (also served as the founding chairman) and Department of Neuroscience; both first in Turkey. He brought in millions of dollars through many research projects to establish research laboratories. He is author of 100+ publications and experienced in photonics, photophysics, photochemistry, photobiology, biophysics, physical chemistry, chemistry of nanoparticles, biomedical engineering, cell biology, nanotoxicology and nanomedicine. He is also interested in application of photonics to agriculture and machine learning. Prof. Ozcelik has three fully equipped research laboratories: A bioscience-lab has a fast spinning disc confocal microscope with many lasers and DIC and dark-field modes, having dual channel imaging setup, a stage incubator; a polarized light microscope, a complete cell culture facility. A nanomaterials-lab is home of many reactors and set-ups for synthesis with scale-up capacity (up to 2 Liters) and a microfluidic flow reactor with 50 mL/sec flow rate and up to 40 mL reactor volume, and many spectrophotometers for optical characterization. A photonic-lab is equipped with glove boxes for device fabrication, capable of optical and electrical device characterizations, two ink-jet material printers able to fabricate 40 mm features. Assoc. Prof. Dr. Tugkan Tuglular: Tugkan Tuglular has got Ph.D. in computer engineering in 1999. As of today, he has more than 60 publications and active record of duties with international and national conferences as well as more than twenty R&D projects with private sector. His current research interests focus on quality assurance of artificial intelligence-based systems through model-based testing and model-based software development. Three related publications are as follows: Container Damage Detection and Classification using Container Images, 2019 (M.Sc. Thesis Co-Advisor) The aim of the thesis is to automate detection of damaged containers carried by ships. In this thesis, we propose a machine learning method which detects damaged containers using the container images to perform statistical damaged / undamaged estimation. We modeled the problem as a binary classification problem, which considers a container as damaged or undamaged. The result obtained from the undertaken studies shows that there is no single best method for visual classification. It is shown how the dataset was created and how the parameters used in the layered structure impact the most suitable model could be created for this study. Rule–based Automatic Question Generation Using Semantic Role Labeling, 2019 (Journal Paper Co-Author) This paper proposes a new rule-based approach to automatic question generation. The proposed approach focuses on analysis of both syntactic and semantic structure of a sentence. Although the primary objective of the designed system is question generation from sentences, automatic evaluation results show that, it also achieves great performance on reading comprehension datasets, which focus on question generation from paragraphs. Especially, with respect to METEOR metric, the designed system significantly outperforms all other systems in automatic evaluation. As for human evaluation, the designed system exhibits similar performance by generating the most natural (human-like) questions. Estimating software robustness in relation to input validation vulnerabilities using Bayesian networks, 2018 (Journal Paper Co-Author) Estimating the robustness of software in the presence of invalid inputs has long been a challenging task owing to the fact that developers usually fail to take the necessary action to validate inputs during the design and implementation of software. We propose a method for estimating the robustness of software in relation to input validation vulnerabilities using Bayesian networks. The proposed method runs on all program functions and/or methods. It calculates a robustness value using information on the existence of input validation code in the functions and utilizing common weakness scores of known input validation vulnerabilities. Using our method, software development teams can track changes made to software to deal with invalid inputs. FYK Technology: FYK Technology (fykmobile.com) is a software development company located on healthcare focused R&D technopark (depark.com) in İzmir, Turkey. The company has been working on several IoT/IoMT projects as well as "Early diagnosis of diabetic retinopathy & Alzheimer using eye images via Machine Learning" project and providing consultancy to build a "Smart hotel minibar, reporting contents & usage using image processing and ML". FYK embraces "Technology for Nature" motto and invest in leading edge technology projects that create value for nature and humanity. FYK employs 30 personal who are mostly computer engineers. The founder and CTO of the FYK, Yalcin Tarkan, is working on his MSc thesis titled "Development of machine learning platform for analysis of mitochondrial features in live-cell images" in Izmir Institute of Technology, İzmir, Turkey.
Offer
Partner Role:
Partner
Topic of the offer:
Izmir Institute of Technology, which is ranked the third best university in Turkey located in Izmir, and FYK Technology, an SME, which is specialized in machine learning applications also located in Izmir, are seeking a consortium or partners for a project application to the EuroNanoMed III 2020 call under the areas:
b) Diagnostics and/or
c) Targeted delivery systems.
Other information:
  • First name, Surname: Tugkan Tuglular
  • Institution/organisation: Izmir Institute of Technology, MitoAI Research Group
  • Country: Turkey
  • E-mail: tugkantuglular@gmail.com
  • Website: https://iyte.edu.tr/
Competences offered:
Izmir Institute of Technology:
MitoAI Research Group at Izmir Institute of Technology is a multidisciplinary research group led by Prof. Dr. Serdar Ozcelik (Dept. of Chemistry) and Assoc. Prof. Dr. Tugkan Tuglular (Dept. of Computer Engineering). A graduate member, Yalcin Tarkan from FYK Technology, of MitoAI Research Group is currently working on his M.Sc. thesis titled "Development of machine learning platform for analysis of mitochondrial features in live-cell images" in Izmir Institute of Technology, İzmir, Turkey. In this project, under the co-advisors Prof. Dr. Serdar Ozcelik and Assoc. Prof. Dr. Tugkan Tuglular, it is aimed to build a smart image-analysis platform to support and ease discoveries in fluorescent microscopic images of living cells to explore structural and behavioral effects on mitochondria in response to the various stimulations of -healthy and diseased- cells. Machine learning tools and techniques are to be employed to analyze time series images to enable researcher to assess mitochondrial features much faster and more precisely.

Prof. Dr. Serdar Ozcelik:
Serdar Ozcelik obtained BSc. and MSc. degrees in engineering physics at Ankara University, Turkey, in 1986 and 1988 respectively. While he was pursuing toward PhD degree in engineering physics, working on to develop methods to correct clinical artifacts on single photon emission computed tomography he was selected for NATO Science Scholarship to pursue PhD degree in USA. He earned his PhD degree in chemistry at City University of New York in 1996, developed mirror-less laser materials based on J-aggregates (a special group of light emitting molecules). He conducted research on receptor-receptor interactions at single molecule level at Pacific Northwest National Laboratory, WA, USA, from 2002 to 2004 as a visiting scientist. Recently, he received Fulbright scholarship to conduct a research on improved efficacy of radiotherapy using nucleus targeted gold nanoparticles at Stanford University, CA, USA. He is directing a funded research project related to photodynamic therapy on lung cancer utilizing mitochondria targeted drug-nanoparticle conjugates sensitized by red-light. Dr. Ozcelik is developing nanomaterials including colloidal quantum dots and methods to fabricate microdisplay using colloidal alloyed quantum dots (another funded research project). He focused on nanomedicine to develop new diagnostics and therapeutics at single cell level using house-made targeted nanoparticles. Dr. Ozcelik is a professor of chemistry at Izmir Institute of Technology (IYTE) where he served as Dean of Faculty of Science, 2011 - 2018. As dean, he established two totally new departments at IYTE: Department of Photonics (also served as the founding chairman) and Department of Neuroscience; both first in Turkey. He brought in millions of dollars through many research projects to establish research laboratories. He is author of 100+ publications and experienced in photonics, photophysics, photochemistry, photobiology, biophysics, physical chemistry, chemistry of nanoparticles, biomedical engineering, cell biology, nanotoxicology and nanomedicine. He is also interested in application of photonics to agriculture and machine learning.
Prof. Ozcelik has three fully equipped research laboratories:
A bioscience-lab has a fast spinning disc confocal microscope with many lasers and DIC and dark-field modes, having dual channel imaging setup, a stage incubator; a polarized light microscope, a complete cell culture facility.
A nanomaterials-lab is home of many reactors and set-ups for synthesis with scale-up capacity (up to 2 Liters) and a microfluidic flow reactor with 50 mL/sec flow rate and up to 40 mL reactor volume, and many spectrophotometers for optical characterization.
A photonic-lab is equipped with glove boxes for device fabrication, capable of optical and electrical device characterizations, two ink-jet material printers able to fabricate 40 mm features.

Assoc. Prof. Dr. Tugkan Tuglular:
Tugkan Tuglular has got Ph.D. in computer engineering in 1999. As of today, he has more than 60 publications and active record of duties with international and national conferences as well as more than twenty R&D projects with private sector. His current research interests focus on quality assurance of artificial intelligence-based systems through model-based testing and model-based software development. Three related publications are as follows:
Container Damage Detection and Classification using Container Images, 2019 (M.Sc. Thesis Co-Advisor)
The aim of the thesis is to automate detection of damaged containers carried by ships. In this thesis, we propose a machine learning method which detects damaged containers using the container images to perform statistical damaged / undamaged estimation. We modeled the problem as a binary classification problem, which considers a container as damaged or undamaged. The result obtained from the undertaken studies shows that there is no single best method for visual classification. It is shown how the dataset was created and how the parameters used in the layered structure impact the most suitable model could be created for this study.
Rule–based Automatic Question Generation Using Semantic Role Labeling, 2019 (Journal Paper Co-Author)
This paper proposes a new rule-based approach to automatic question generation. The proposed approach focuses on analysis of both syntactic and semantic structure of a sentence. Although the primary objective of the designed system is question generation from sentences, automatic evaluation results show that, it also achieves great performance on reading comprehension datasets, which focus on question generation from paragraphs. Especially, with respect to METEOR metric, the designed system significantly outperforms all other systems in automatic evaluation. As for human evaluation, the designed system exhibits similar performance by generating the most natural (human-like) questions.
Estimating software robustness in relation to input validation vulnerabilities using Bayesian networks, 2018 (Journal Paper Co-Author)
Estimating the robustness of software in the presence of invalid inputs has long been a challenging task owing to the fact that developers usually fail to take the necessary action to validate inputs during the design and implementation of software. We propose a method for estimating the robustness of software in relation to input validation vulnerabilities using Bayesian networks. The proposed method runs on all program functions and/or methods. It calculates a robustness value using information on the existence of input validation code in the functions and utilizing common weakness scores of known input validation vulnerabilities. Using our method, software development teams can track changes made to software to deal with invalid inputs.

FYK Technology:
FYK Technology (fykmobile.com) is a software development company located on healthcare focused R&D technopark (depark.com) in İzmir, Turkey. The company has been working on several IoT/IoMT projects as well as "Early diagnosis of diabetic retinopathy & Alzheimer using eye images via Machine Learning" project and providing consultancy to build a "Smart hotel minibar, reporting contents & usage using image processing and ML". FYK embraces "Technology for Nature" motto and invest in leading edge technology projects that create value for nature and humanity. FYK employs 30 personal who are mostly computer engineers. The founder and CTO of the FYK, Yalcin Tarkan, is working on his MSc thesis titled "Development of machine learning platform for analysis of mitochondrial features in live-cell images" in Izmir Institute of Technology, İzmir, Turkey.
Offer
Partner Role:
Partner
Topic of the offer:
The two closely collaborating institutions, Institute of Macromolecular Chemistry, Czech Academy of Sciences (IMC CAS) and the Center for Advanced Preclinical Imaging, 1st Medical Faculty, Charles University (CAPI MF1 CUNI) cover advanced expertise in the development of stimuli-responsive polymer and nanoparticle diagnostic and therapeutic systems. These include, e.g., anticancer systems, therapeutics for Wilson`s disease, haemochromatosis, radio-immunotherapeutics or photoacoustic and MRI contrast agents.
Other information:
Competences offered:
System design, synthesis of low molecular weight compounds and polymers, physico-chemical nanosystems characterization including advanced instrumental techniques, radiolabeling and fluorescence labeling, in vitro degradation and drug release studies. Biological testing: in vitro testing on cell cultures; in vivo biodistributions, imaging and therapeutic experiments; full range of preclinical in vivo imaging techniques for small laboratory animals along with GMO animal facility are available; GLP accreditation in 2020.
Examples of publications:
1. J. Controlled Release 273 (2018) 131-138, DOI: 10.1016/j.jconrel.2018.01.026
2. J. Controlled Release 268 (2017) 78-91, DOI: 10.1016/j.jconrel.2017.10.010
3. Nanoscale 9(43) (2017) 16680-16688, DOI: 10.1039/c7nr05456d

Web links:
https://www.imc.cas.cz/en/umch/o_supramol.html
www.capi.lf1.cuni.cz/en

Offer
Partner Role:
Partner
Topic of the offer:
I propose the development of novel multifunctional nanomedicinal formulations that target and deliver potent drug cocktails at tumor sites in a highly specific manner. The proposed formulations comprise the synthesis of polymer and RNA based nanomedicines that can carry multiple drug molecules and can be activated to release their payload by ultrasound waves. The proposed ultrasonic mediated therapeutic modality is highly advantageous compared to current drug monotherapies in that it can co-deliver multiple anticancer drugs and augment their synergistic activity, which could potentially reduce or even eliminate the development of drug resistance. In addition, the proposed nanomedicines exert additional cytotoxicity due to their capacity to generate cytotoxic products upon ultrasound irradiation in a highly targeted manner at the diseased areas.
Other information:
  • First name, Surname: George Pasparakis
  • Institution/organisation: University of Patras
  • Country: Greece
  • E-mail: gpasp@chemeng.upatras.gr
  • Website: www.gpnanolab.com
Competences offered:
synthesis and characterization of small synthons (i.e. prodrugs), (block-) copolymers for drug delivery applications, responsive nanomaterials for remotely controlled therapeutics (i.e. by laser, ultrasound, etc.), plasmonic nanomaterials for targeted therapeutics, and polymer-drug conjugates for precision medicine. In addition, expertiese in liposome based nanofmrulations, and development of in vitro/vivo models for combinational therapies.
Offer
Partner Role:
Partner
Topic of the offer:
I am interseted of formulation of nanosized polyelectrolyte complexes from natural polyelectrolyte and their application as drug delivery systems.
Other information:
Competences offered:
Formulation and characterization of polyelectrolyte multilayers; Formulation and characterization of nanoparticles; Immobilization of drugs by different techniques; Investigation of drug release kinetics by spectroscopic method; Thermal analysis by DSC Kinetic studies by QCM and SPR Investigation of surface morphology by AFM.
Offer
Partner Role:
Partner
Topic of the offer:
Targeted delivery systems and regenerative medicine
Other information:
  • First name, Surname: Erem Bilensoy
  • Institution/organisation: Hacettepe University
  • Country: Turkey
  • E-mail: eremino@hacettepe.edu.tr
  • Website: www.erembilensoy.com
Competences offered:
BilensoyLab research group is experienced in in vitro and in vivo evaluation nanoparticulate drug delivery systems for intravenous, oral or mucosal routes. We are able to provide a wide range of in vitro characterization techniques, cell culture studies including cytotoxicity, cellular uptake, apoptosis assays as well as co-culture studies. We have established 3-D spheroid tumor models for breast cancer (drug sensitive and drug resistant), hepatocellular carcinoma, non-small cell lung cancer. main research of the group focus on tumor targeted delivery systems thourhg folate receptors and cell membrane cholesterol but also interested in antiviral drug delivery systems. For more info please check website.
Offer
Partner Role:
Partner
Topic of the offer:
We are a Turkish R&D team on the gelatin, collagen and leather producing.With over 10 years of experience, our experts and resources are equipped to meet testing, timeline and product needs. As regulations change and technology is created or innovated, our knowledge and industry expertise ensure products and business are prepared to meet evolving demands. Our main areas are: • Textile and Garment Products • Finished Leather and Footwear • Food & Feed • Food Contacts • Cosmetic • Toys • Stationery • Child Care Products • Personal Care Products • Paper Products ( Towel Napkins,
Other information:
  • First name, Surname: Ecem ozdemir
  • Institution/organisation: KAZLIÇEŞME
  • Country: Türkiye
  • E-mail: ecem.ozdemir@etkinproje.com
  • Website: https://halavet.com.tr/
Competences offered:
We could give support on collagen, gelatin and leather material producing, test analyzes.
Offer
Partner Role:
Partner
Topic of the offer:
Our group is focused in translational aspects of skeletal biology. We study skeletal mechanisms of disease and develop new therapeutic strategies for bone/cartilage disease and regeneration. Our research includes identification of the pathological mechanism, development of precision medicine treatments and drug testing in bone and cartilage organoids and in vivo models. We offer our expertise in any translational aspect of skeletal biology. See methodologies below.
Other information:
Competences offered:
We are a multidisciplinary research group integrating several research IP and research lines performing the following methodologies: - Organoid strategies for bone and cartilage - Bone and cartilage tissue culture engineering - Bone and cartilage drug delivery systems - Skeletal iPSC studies - Application and testing of osteogenic factors such as BMPs, FGFs, WNTs, PTH, etc. - Murine models of low bone density and ER stress - Toxicology and drug testing in zebrafish - Zebrafish regeneration - Skeletal dysplasia studies in combination with the International skeletal dysplasia registry - Genetic identification of skeletal pathology - Study of mechanistic signaling pathways in bone and cartilage - Skeletal biomaterial development and testing - Gene editing in osteogenic cell lines - Possibility of performing micro-CT and fracture studies in collaboration with specialized cores. - Possibility of performing Genomic and Exome analysis for skeletal dysplasias cases.
Offer
Partner Role:
Partner
Topic of the offer:
Our research involves the design and synthesis of cancer-targeted conjugates bearing different guiding moieties such as peptides, steroids, folic acid, carbohydrates. The conjugates may carry a variety of anticancer agents and cytotoxic compounds, or imaging tags for real-time monitoring in cancer cells and PDT chemotherapy. We are searching for partners to evaluate the efficacy and targeting ability of the new drug conjugates. Furthermore, we offer to SMEs expertise to develop novel theragnostic tools and drug delivery systems.
Other information:
  • First name, Surname: Vasiliki Sarli
  • Institution/organisation: Department of Chemistry, Organic chemistry lab, Aristotle University of Thessaloniki
  • Country: Greece
  • E-mail: sarli@chem.auth.gr
  • Website: https://users.auth.gr/~sarli/examples.html
Competences offered:
Euronanomed III, EUROPEAN INNOVATIVE RESEARCH &TECHNOLOGICAL DEVELOPMENT PROJECTS IN NANOMEDICINE
Offer
Partner Role:
Partner
Topic of the offer:
Physico-chemical characterization of nanoparticles, analytical method development and validation
Other information:
  • First name, Surname: Marlène Klein
  • Institution/organisation: UT2A / ADERA
  • Country: France
  • E-mail: marlene.klein@univ-pau.fr
  • Website: www.ut2a.fr
Competences offered:
- Multi-dimensional physico-chemical characterization of polymers and nanoformulations by A4F-UV-MALS-(RI or ICPMS) online : granulometry (size, size distribution), shape, aggregation state, stability, encapsulation efficiency, chemical composition - Determination of size and concentration of metallic nanoparticles by Single particle ICPMS - Granulometry by DLS according to ISO reference document. - Analytical method development and validation expertise in a nearly GLP implemented environment together with external QA audits. - Speciation and trace metal analysis by HPLC and GC-ICPMS
Offer
Partner Role:
Partner
Topic of the offer:
Development of next generation vaccines for infectious diseases. Today, many conventional vaccines do not provide sufficient protection against infectious diseases though their side effects. The progress in molecular microbiology and genetics as well as nanobiotechnology offers us to develop next-gen vaccines with reduced side effects/risks and elevated levels of immunogenicity and protection.
Other information:
Competences offered:
I have expertise on the development of recombinant DNA- and protein-based vaccines. - Microbiology techniques - Recombinant DNA techniques - Protein purification and analysis - Genomics and bioinformatics - Vaccination of mice - ELISA
Offer
Partner Role:
Partner
Topic of the offer:
We are interested in Diagnostics and Targeted delivery systems.
Other information:
  • First name, Surname: Viola Tokarova
  • Institution/organisation: UCT Prague
  • Country: Czech Republic
  • E-mail: tokarovv@vscht.cz
  • Website: http://biomimetic-lab.vscht.cz/
Competences offered:
We are experienced in nano- and microparticulate systems, specific adhesion studies based on antibody-antigen interactions, microfluidic systems, encapsulation of active substances (e.g., enzymes), nano- and microstructured surfaces.
Offer
Partner Role:
Partner
Topic of the offer:
Coating technologies. Interested in cooperation projects under EURONANOMED JOINT CALL “EUROPEAN INNOVATIVE RESEARCH & TECHNOLOGICAL DEVELOPMENT PROJECTS IN NANOMEDICINE”.
Other information:
  • First name, Surname: Juan Antonio Ruiz Fuentes
  • Institution/organisation: Nadetech Innovations
  • Country: España
  • E-mail: juanan.ruiz@nadetech.com
  • Website: www.nadetech.com
Competences offered:
We are specialized in the development of coating technologies. We supply our coating equipment and provide technical support, offering personalized solutions for different coating techniques via dip-coating, spray coating and electrospinning. We are strongly committed to innovating laboratory processes in order to make easier and safer the work of scientists and companies. Nadetech Innovations is able to adapt the most advanced coating technologies to your particular requirements, offering an individualized service. The applications of our coating technologies and services are diverse and our customers come from a broad array of industries including biomedicine, nanotechnology, photovoltaic cells, crystals and other advanced materials, sensors, hydrophobic surfaces, food industry, fuel cells…
Offer
Partner Role:
Partner
Topic of the offer:
Physico-chemical characterization of nanoparticles. Analytical method development and validation.
Other information:
  • First name, Surname: Marlène Klein
  • Institution/organisation: UT2A / ADERA
  • Country: France
  • E-mail: marlene.klein@univ-pau.fr
  • Website: www.ut2a.fr
Competences offered:
- Multi-dimensional physico-chemical characterization of polymers and nanoformulations by A4F-UV-MALS-(RI or ICPMS) online : granulometry (size, size distribution), shape, aggregation state, stability, encapsulation efficiency, chemical composition - Determination of size and concentration of metallic nanoparticles by Single particle ICPMS - Granulometry by DLS according to ISO reference document. - Analytical method development and validation expertise in a nearly GLP implemented environment together with external QA audits. - Speciation and trace metal analysis by HPLC and GC-ICPMS
Offer
Partner Role:
Partner
Topic of the offer:
We are interested in regenerative medicine and targeted drug delivery topics. We are manufacturing dextran nanoparticles for anticancer drug delivery with targeting molecules. We are manufacturing hydroxyapatite nanoparticles for bone implants, we 3D print bone and cartilage implants. We make nanofibres by solution blow spinning, for tissue regeneration.
Other information:
  • First name, Surname: Tomasz Ciach
  • Institution/organisation: Warsaw University of Technology
  • Country: POLAND
  • E-mail: tomasz.ciach@pw.edu.pl
  • Website: www.biomedlab.pw.edu.pl
Competences offered:
Competences: Various nanoparticles manufacturing by molecular chemistry and nanoprecipitation, advanced organic chemistry, confocal, fluorescent and electron microscopy, cell labs, 3D printers, Z-Sizer... Advance surface modification technologies in place.
Offer
Partner Role:
Partner
Topic of the offer:
New biocompatible polymeric nanocarriers and/or metallic nanoparticles specifically designed to assist unmet needs in the biomedical field as increase solubility, bioavailability or tracking. We aim at being involved in research projects which require controlling properties of those nanosystems to exploit their unique capability for sustained drug delivery, diagnosis and biosensing.
Other information:
  • First name, Surname: Jose Luis Muñoz
  • Institution/organisation: Nanotechnology in Healthcare platform, LEITAT technological center.
  • Country: Spain
  • E-mail: jlmunoz@leitat.org
  • Website: https://projects.leitat.org/
Competences offered:
We offer strong expertise on the following fields: • Rational design, synthesis and characterization of smart nanocarriers regarding the route of administration of the final formulation. Those nanocarriers are biocompatible and capable of performing a controlled and targeted cargo release upon external stimuli if required. • Rational design, synthesis and characterization of biofunctionalized inorganic nanoparticles with specific responses for medical diagnosis, therapy, theranostics and biosensing • Stability testing based on durability, sustained release and transformation of the nanosystems and the final formulations in biologically relevant environments.
Offer
Partner Role:
Partner
Topic of the offer:
My offer topics are diagnostic and targeted delivery systems.
Other information:
Competences offered:
Recombinant production of proteins that can be used in vaccine, diagnosis, treatment and drug targets, Cloning the genomic sequence into vectors and constructing a library In vitro evaluation of the effectiveness of synthesized drugs and drug delivery systems on microorganisms
Offer
Partner Role:
Partner
Topic of the offer:
Development of nano sensor for easy and quick diagnostic application We want to develop easy blood testing system using nanosensor. Nanosensor structures will have a micropillar, Nanochannels AAO filters. In this system, we want to use electrochemical sensor as a sensing model. Therefore, we can develop reusable/single use sensing materials, which based on biological and chemical phenomena.
Other information:
  • First name, Surname: Cihat TASALTIN
  • Institution/organisation: TUBITAK MRC MI
  • Country: Türkiye
  • E-mail: cihat.tasaltin@tubitak.gov.tr
  • Website: http://me.mam.tubitak.gov.tr/en
Competences offered:
Our Research Group is making pioneer studies on biosensors research by combining the expertise of material science and medical devices. The main focus areas of the group are;Biosensors for patient monitoring, Bio-MEMS, early detection of infections and diseases. If there are any companies or universities interested in our idea, we would like to take part in this call, we can contribute to this call by nanomaterials synthesis, design, and fabrication of microfluidics channels, Nanopillars, AAO filters surface integration of bio-nanomaterials. In the Our infrastructure has 1000 class clean room and etching, patterning equipment. Also, We have general chemistry laboratories for synthesis and characterization. http://me.mam.tubitak.gov.tr/en/research-areas/bio-nano-materials-group
Offer
Partner Role:
Partner
Topic of the offer:
FibroHeart project will focus on cardiovascular fibrosis whose origin is related to almost all cardiovascular chronic disease worsening the patient prognosis and reducing their lifespan. A major cause of myocardial fibrosis comes from aging, valve alterations, hypertension, or genetic disorders that lead to excessive collagen deposition within vessels, atrial, pericardial and perivascular regions that often manifested as dysfunctional heart events. Although cardiovascular fibrosis collectively represent a major medical and socio-economic burden, their molecular diagnosis, pathogenic mechanisms and rationale treatment are poorly understood. We propose the utilization of developed biotechnological tools to reach the pathological heart with a potential new theragnostic nanoparticle based on a design modular protein with anti-fibrotic/diagnostic capabilities demonstrated in rodents to observe the preclinical effectiveness in big mammals and to detect its target in blood test from patients. The final report will be presented to IAMP for its approval to enter in fase I of clinical trials. The general objective of FIBROHeart is to advance the state of the art with respect to: (1) the treatment of myocardial fibrosis testing preclinical strategies based on target inhibition in big experimental models to confirm the novel preventative strategy demonstrated in rodents. (2) The development of strategies to specifically reach myocardial fibroblasts changing the formulation of the anti-fibrotic nanoparticle and scale both theragnostic molecules to obtain commercial dosage of the compound. (3) The diagnostic tools (the nanoparticle as biomarker) through the clinical studies of a unique and well-characterized cohort of patients suffereing from cardiovascular fibrosis (left ventricle, atrial and aortic fibrosis will be included) to provide a standardized diagnosis for patient stratification and research across Europe. The workplan spans from cellular and animal models and basic research, improvement of treatment and diagnostic methods, writing the dossier to be presented looking for the acceptance to reach the clinical trials and assessment of innovative, targeted theragnostic strategies. The consortium partners have an outstanding track record in protein nanodesign, nano-compounds high scale production, myocardial basis of disease, cardiology and clinical research. Specialized expertise will be made available by the SMEs involved to develop novel theragnostic tools for tailored treatment approaches.
Other information:
Competences offered:
Call for clinical partners: Tasks: 1. Acquisition of blood samples and clinical data collection of one or more of the following group of patients: Patients with Atrial fibrillation (with and without fibrosis) Patients with Aortic stenosis (with and without fibrosis) Patients with Hypertension (with or without myocardial remodeling) Patients with Aortic fibrosis 2. Performance of ELISA assays to measure target protein levels from plasma samples of those patients
Offer
Partner Role:
Partner
Topic of the offer:
Field of interest: 1. Skin regeneration 2. Bone and cartilage repair/regeneration, MAJOR RESEARCH INTEREST OF THE GROUP • Biocompatibility assessment of materials proposed for bone and skin engineering • The potential of MSC secretome for skin and osteo-articular regenerative therapy • Development of skin and bone 3D organotypic cultures for in vitro study of therapeutic compounds
Other information:
  • First name, Surname: Irina Titorencu
  • Institution/organisation: Institute of Cellular Biology and Pathology “Nicolae Simionescu”
  • Country: Romania
  • E-mail: irina.titorencu@icbp.ro
  • Website: www.icbp.ro
Competences offered:
• Cell culture techniques • Biocompatibility assessment for organic and inorganic materials • 2D and 3D culture systems • Histological processing and staining • Ultracentrifugation techniques for exosomes isolation • Fluorescence microscopy • Molecular biology (Western blot, PCR, RT-PCR, qPCR, transfections)
Offer
Partner Role:
Partner
Topic of the offer:
Production of some nanocarrier controlled drug delivery materials based on double emulsion technique for combined therapy method treatment of some cancer types
Other information:
Competences offered:
Focused targeting to cancer cells will be possible by using mesenchymal stem cells and time of controlled delivery will be tunable by optimising the size and constitution of the system. Delivery system will be an optimised original ester (from possible configurations) based on a block copolymeric system packed together with DOX and ICG.
Offer
Partner Role:
Partner
Topic of the offer:
We develop and fabricate lab-on-a-chip (LOC) devices for 3D cell culture. LOC enable us to mimic the microenvironment of cells and thus in vivo conditions. We investigate invasion and extravasation of cancer cells under various settings with and without drugs using confocal microscopy followed by quantitative image analysis. Our goal is to develop LOC and associated methods to realize early diagnosis of cancer, personalized medicine and successful drug discovery.
Other information:
  • First name, Surname: Devrim Pesen Okvur
  • Institution/organisation: Izmir Institute of Technology
  • Country: Turkey
  • E-mail: dpesenokvur@gmail.com
  • Website: https://mbg.iyte.edu.tr/en/home-page/
Competences offered:
organ-on-a-chip 3D cell culture Confocal microscopy Image analysis Invasion-, migration-, extravasation-on-chip assays Cytotoxicity in 3D cell culture Molecular cellular biology assays
Offer
Partner Role:
Partner
Topic of the offer:
Development of next generation vaccines for infectious diseases. Today, many conventional vaccines do not provide sufficient protection against infectious diseases though their side effects. The progress in molecular microbiology and genetics as well as nanobiotechnology offers us to develop next-gen vaccines with reduced side effects/risks and elevated levels of immunogenicity and protection.
Other information:
Competences offered:
I have expertise on the development of recombinant DNA- and protein-based vaccines. - Microbiology techniques - Recombinant DNA techniques - Protein purification and analysis - Genomics and bioinformatics - Vaccination of mice - ELISA
Offer
Partner Role:
Partner
Topic of the offer:
We are producing bio-degradable nano-fibers with Solution Blow Spinning technique in our laboratory. This technique is at least 50% cheaper than electrospinning technique which is the most widely used for nanofiber production. We are producing bio-degradable nanofibers for enhancing shelf life of foods and also improving mechanical and barrier properties of packaging materials. Bio-degredable nanofibers produced with our technique can be a valuable tool for nano-medicine call such as regenerative medicine, diagnostics and targeted delivery systems. Nanofibers have very low specific weight and very large surface area, which are vey important tasks for controlled release of specific materials held in the nanofibers. Hydrophobic and Bio-degradable properties of nano-fibers prevent organs from sticking after surgery. This production technique is at least 50% cheaper than electro-spinning and so, it is also commercially applicable.
Other information:
Competences offered:
We can produce nanofibers with solution blow spinning technique in our laboratory and also we can perform some characteristic tests of nanofibers such as mechanical properties, thermal properties, antioxidant and antimicrobial properties. Also, we have experience about other nanofiber characterization analyses such as Scanning Electron Microscopy, Transmission Electron Microscopy, FT-IR spectrum, specific surface area measurements etc.
Offer
Partner Role:
Partner
Topic of the offer:
Cancer related diagnostics and prognostics
Other information:
Competences offered:
Design and fabrication of microsystems in Si, Glass and Polymers for medical and life sciences research applications : microfluidic platforms, miniaturized sensors, diagnostics devices.
Offer
Partner Role:
Partner
Topic of the offer:
EURONANOMED JOINT CALL “EUROPEAN INNOVATIVE RESEARCH & TECHNOLOGICAL DEVELOPMENT PROJECTS IN NANOMEDICINE”.
Other information:
  • First name, Surname: Jordi Villà-Freixa
  • Institution/organisation: Universitat Internacional de Catalunya
  • Country: Spain
  • E-mail: jvilla@uic.cat
  • Website: http://mon.uvic.cat/cbbl
Competences offered:
Our lab works in computational biochemistry and biophysics approaches, focussing on structure-function relationships of protein complexes, both from static (modelling, characterization of PPI and protein-small molecule interactions) and dynamic (collective movements, enzymatic reactivity, small molecule trasnport) pounts of view. We look for a consortia aiming at characterizing drug delivery systems in a translational medicine enviroment
Offer
Partner Role:
Partner
Topic of the offer:
Our main research interest is biopolymeric especially silk based biomaterials and their biotechnological applications (medical textile, wound dressings, biosensor, encapsulation of natural bioactive compound, controlled and targeted release of natural compounds).
Other information:
Competences offered:
Our research group does research mainly on fractionation and purification of natural compounds from plant extracts. Some of our research is related to production of natural compounds for cosmetic, food, and health, and nanomaterial applications. We have mainly focused on encapsulation of plant derived natural compounds in the form of biopolymeric micro/nano capsules/spheres and nanofibers for industrial applications.
Offer
Partner Role:
Partner
Topic of the offer:
Development of point-of-care diagnostic systems of direct detection. We have developed an extremely fast and simple immunoassay format that, using magnetic beads and a polymeric enzyme signal amplifier, provides sensitive detection in 15-40 min. We also developed a novel type of paper microfluidic electrode that allows performing on-chip most of the magnet-assay in whole blood, including magnetic bead washing and electrochemical detection, with little user intervention. This technology has been tested for detection of MMP-9 (cancer and stroke) and Plasmodium lactate dehydrogenase (malaria). We would like to exploit our technology in additional diagnostic fields. Our main interest would be to substitute now our enzymatic labels by nanolabels that could be detected straightforward (without having to add an enzymatic substrate or similar), for instance colorimetrically, fluorescently or electrochemically. A second interest would be automating our simplified assay formats using inexpensive and simple platforms of any type.
Other information:
Competences offered:
- Wide experience in the optimization of fast assays (simplified ELISA, extremely short magnetic bead assays). - Wide experience in the optimization of electrochemical biosensors. - Limited experience in the production of enzyme-less electroactive nanolables using gold nanoparticles. - Limited experience in the production of paper microfluidic devices. - Facilities and experience for the validation of assays and biosensors in a clinical environment.
Offer
Partner Role:
Partner
Topic of the offer:
We are interested in the call 1 topic of the call 2020 "European Innovative Research & Technological Development Projects in Nanomedicine": *Targeted delivery systems
Other information:
Competences offered:
We aim to create biodegradable, biocompatible, cost-effective, new targeted drug delivery systems (drug-loaded magnetic cored polymeric system) that do not harm healthy cells for cancer therapy on in vitro and in vivo systems. This study is also planned to investigate the changes in molecular signaling pathways and in silico modeling studies.
Offer
Partner Role:
Partner
Topic of the offer:
Implant-related infection is still one of the most frequent and severe complications associated with the use of biomaterials leading to removal surgery and even death. Even when treated, initial infection can cause lifelong chronic complications such as osteomyelitis in the case of orthopedic implants. Preventing the initial bacterial colonization on biomaterial surfaces is the key to reducing the prevalence of biomaterial-related infections. That is why we are interested in the prevention of biomaterial related infections and especially -but not limited to- nanoustructured titanium implants. Our research group that comprises of researchers in bioengineering and nanotechnology/nanomedicine fields from Hacettepe University and Ankara Haci Bayram Veli University. Our main research areas are: Generation of nanostructures on titanium implants. Prevention of biomaterial related infections Improvement of biocompatibility of biomaterials Surface modification and functionalisation of biomaterials using plasma polymerization technique Biocompatibility testing of biomaterials Materials characterization Cell culture In addition, with our experience in the biomedical industry, we are also highly qualified in performing risk analysis for medical devices and designing biocompatibility testing accordingly. We're also open to explore other possible areas of collaboration related to these subjects.
Other information:
  • First name, Surname: Ebru Akdogan
  • Institution/organisation: Ankara Hacı Bayram Veli University & Hacettepe University
  • Country: Turkey
  • E-mail: ebru.akdogan@hbv.edu.tr
  • Website: hacettepe.edu.tr, hacibayram.edu.tr
Competences offered:
Generation of nanostructures on Ti surfaces Surface characterization using SEM, FTIR, XRD, XPS, contact angle measurements Biocompatibility testing Plasma surface modification and biomolecule immobilisation on various biomaterial surfaces Development of bacteria anti-fouling surfaces Testing of bacteria-repelling properties of surfaces Testing of the inhibition of biofilm formation on surfaces
Offer
Partner Role:
Coordinator
Topic of the offer:
Reversal of acquired drug resistance
Other information:
Competences offered:
I have experienced to generate acquired drug resistance cancer cells and to evaluate the genetic and epigenetic mechanisms leading to drug resistance, in vitro. I have an idea to overcome acquired resistance in cancer cells by spesific targeting nanoparticles. In our previous studies, we determined the reversal of different chemotherapeutic drugs based resistance by solid lipid nanoparticles. Therefore, I need collaboration for nanoparticles as well as in vivo analysis.
Offer
Partner Role:
Partner
Topic of the offer:
Inovenso Ltd. Co is an electrospinning company and supplier of industrial-level and laboratory-scale nanofiber production machines, with years of research and development (R&D) since 2007. It is based in Turkey, founded in Istanbul Technical University and the sister company is located at Boston-USA. Inovenso aims at providing reliable and versatile electrospinning machines with reliable technical support in research scale and industrial scale.
Other information:
  • First name, Surname: Yusuf Keskin
  • Institution/organisation: Inovenso Teknoloji Ltd Sti
  • Country: Türkiye
  • E-mail: yusuf.keskin@inovenso.com
  • Website: www.inovenso.com
Competences offered:
Nanofibers are characterized by two main properties due to its nanoscale diameter; extremely high surface to volume ratio and defects-free structure on the molecular level. These two properties make nanofibers interesting candidates in research for many applications. 1. Drug delivery systems: the versatility of composition of nanofibers and the large surface area make them excellent candidates for drug delivery particularly through the transdermal route for the delivery of different drugs as antibacterial and wound healing agents 2. Tissue engineering: nanofibers show excellent results as scaffolds for tissue regeneration. The nanofibers are usually loaded with chemicals that promote the recruitment of proliferating cells. A large amount of fabrication methods have already been demonstrated nanofibers from various materials. Compared with all of other Technologies electrospinning , has been recognized as the simple and versatile fiber-making technology for fabricating nanofibers. It is possible to produce nanofibers with electrospinning from a great variety of materials such as polymers, composites, and ceramics.
Offer
Partner Role:
Partner
Topic of the offer:
We are interested to find partners for tumor ablation using HIFU (ultrasonic technology) combined with shell core metallic nanoparticles. We are developing core shell SPIONs where the core can be loaded with cytotoxics. Use of HIFU will permit do deliver the drug on demand with a high localized payload delivery. Partners working on HIFU technology, spheroids and murin PDX models are welcome.
Other information:
  • First name, Surname: Raphaël DUVAL
  • Institution/organisation: Naturality Research & Development
  • Country: Spain
  • E-mail: naturality@sfr.fr
  • Website: wwww.naturality-essentials.net
Competences offered:
Core shell SPIONS are very promizing nano-objects with imaging properties that can be tuned by synthesis of hybrid shells (Gd doping for example). The internal core can accept in principle any type of active molecule, thus offering additional improved effciciency to the HIFU ablation effect. Concomitantly, MRI detection of the NPs in the surrounding of the tumor will help to localize the HIFU zone available for treatment.
Offer
Partner Role:
Partner
Topic of the offer:
Our idea aims to develop new formulations of biomaterials composed of biomolecules, borate and phosphate groups for new generation borophosphate glasses that possess the potential of “boroapatite formation via biodegradation” for orthopedic applications.
Other information:
Competences offered:
If there are any companies or universities interested in our idea, we would like to take part in this call and we can form consortium with any groups which are interested in a new generation borophosphate glasses for orthopedic applications. We can contribute to this call by materials synthesis & characterization and preliminary bioactivity tests.
Offer
Partner Role:
Partner
Topic of the offer:
1. Production and characterization of multifunctional hybrid nanoparticles with defined luminescent characteristics
2. Development of novel bioanalytical platforms based on nanomaterials for highly sensitive quantification and imaging of disease biomarkers and molecules of interest in environment and food control
3. Development of optical biosensors for (bio)molecules using nanoparticles as optical tags: application to clinical, food safety control, industrial process control and environmental applications.
Other information:
  • First name, Surname: JOSE MANUEL COSTA-FERNANDEZ
  • Institution/organisation: University of Oviedo / Department of Physical and Analytical Chemistry
  • Country: Spain
  • E-mail: jcostafe@uniovi.es
  • Website: https://geab.grupos.uniovi.es/en
Competences offered:
a. Characterization of hybrid nanoparticles using molecular and elemental spectroscopic methodologies: quantification of nanoparticle number concentration and biomolecule:nanoparticle surface ligand density.

b. Development and analytical characterization of optical sensors based on nanomaterials

c. Development of multifunctional imaging nanoplatforms

d. Toxicity assessment of hybrid nanomaterials
Offer
Partner Role:
Partner
Topic of the offer:
The main idea is to transfer different amino acids, proteins or lipids to the cells, especially gamete cells like sperm and oocyte by cyclodextrins as a targeted delivery system. In addition to the potential modifications of the cell function by those delivered substances their impact on the ability of those cells to undergo freezing or cryotolerance is also in the scope. In the previous studies we have transferred cholesterol molecule to the sperm cell membrane by cholesterol preloaded cyclodextrin to improve their freezability and cell functions.
Other information:
Competences offered:
Stimulatory or modifying effects of water insoluble amino acids (AA) or lipid based components on the gamete function and their cryotolerance is not known. Their combination with cyclodextrins enhances their solubility and enable the user to deliver them on cell membrane. Formulation of different freezing protocols including these combinations (CD-AA/protein/lipid) might improve post-thaw viability of various cell lines (especially gametes).
Offer
Partner Role:
Coordinator
Topic of the offer:
We are first interested in the development and assay of nanoparticles and supramolecular nanostructures with antimicrobial properties, especially Gram-positive Streptococcus pneumoniae and Gram-negative Pseudomonas aeruginosa and Haemophilus influenzae. We have identified several compounds affecting the membrane or the cell wall of these pathogens, ranging from small organic molecules to peptides and enzymes (enzybiotics), and inducing either lytic or non-lytic effects. We would like to proceed further with their multivalent display on nanostructures, so as to increase their efficiency and to evaluate the targeting and controlled triggering of bactericidal events. In any case, we are also happy to consider participating as partners in other proposals within the call topics that might require studies on protein structure and engineering.
Other information:
Competences offered:
1.- Expertise in protein structure, stability and engineering.
2.- Biophysical studies on protein-protein and protein-ligand interactions. Spectroscopical analyses.
3.- Microbiological assays on planktonic and biofilm cultures of bacteria.
4.- Enzymes with antimicrobial activity (enzybiotics).
5.- Functionalization of polyhydroxyalkanoates (PHAs) as biodegradable and biocompatible supports for biomedical applications.
Offer
Partner Role:
Partner
Topic of the offer:
Natural products: we isolate natural anticholinesterase inhibitors and anticancer agents from plants and fungi with activity guidance. In addition, we investigate the structure-activity relationships of the molecule in natural products.
Other information:
Competences offered:
We isolate bioactive compounds from various plants and fungi as activity guided and carry out in vitro tests in our laboratory. Our laboratory and researcher infrastructure are sufficient. In addition to activity guided isolations in our laboratory, cytotoxic tests are performed against various cancer cell lines. In addition, anticholinesterase, urease, tyrosinase, alpha-glucosidase enzyme inhibition activities are investigated.
Offer
Partner Role:
Partner
Topic of the offer:
I propose an innovative anti- tumor combinatorial approach to overcome the imbalance immune effector T cells/suppressor cells to accomplish a robust and a specific CAR T cell-response against cancer.
Other information:
Competences offered:
CAR T pioneered and further developed at Prof. Eshhar’s lab, and further lead by Dr. Anat Globerson Levin. CARs are genetically engineered modular receptors that endow T cells with the ability to directly bind and attack tumor cells in a MHC-independent manner, However, a major obstacle in applying CAR T cell therapy to solid tumors is the immunosuppressive tumor microenvironment (TME). We specialized in CAR T cell against solid tumors and hematology malignancies, improving manufacturing of CAR T cell, making CAR T administration safer, making CAR T cell escape from exhaustion state.
Offer
Partner Role:
Partner
Topic of the offer:
For this or similar call
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”
Other information:
Competences offered:
Synthesis of novel monodispersed nanohydrogels with biocompatibility that can be targeted with peptides, labeled with NIR probes and loaded with drugs
Offer
Partner Role:
Partner
Topic of the offer:
Field of interest: 1. bone and cartilage repair/regeneration, and 2. comprehension of molecular mechanisms of osteo-chondrogenesis.

In order to revert a diseased cell phenotype, repair a damage and regenerate a tissue, we are particularly interested in the development of:
- injectable nucleic acid based drugs (siRNA, antagomiRNA, miRNA) after demonstration of the specific role of their biological target in specific cellular experimental models
- engineered cells to be used in implantable constructs (cell-based approach)
Other information:
Competences offered:
- set up of human primary cell cultures from bone, cartilage and intervertebral disc samples
- isolation and characterization of human osteoclasts from peripheral blood cells
- isolation and characterization of human mesenchymal stem cells (hMSCs) from umbilical cord Wharton Jelly
- osteoblasts/osteoclasts co-culture
- 3D cell cultures by using biomaterials, decellularized extracellular matrix, and Rotary Cell Culture System (RCCS bioreactor, SyntheconTM) with HARV (High Aspect Ratio Vessel) technology
- cell culture in controlled hypoxia environment by using X3 Hypoxia Hood And Culture Combo–BioSpherix
- gene silencing
- cell transfection
- molecular biology analysis (evaluation of gene expression, functional analysis, Luc assay, Chromatin Immunoprecipitation)
Offer
Partner Role:
Partner
Topic of the offer:
c) Targeted delivery systems
b) Diagnostics
Other information:
  • First name, Surname: Serap DERMAN
  • Institution/organisation: Yıldız Teknik Üniversitesi
  • Country: Türkiye
  • E-mail: serapacar5@gmail.com
  • Website: https://www.dermanslab.com
Competences offered:
Derman'S Functional Nano-Biomaterials and Peptide Chemistry Research Group is located in the Bioengineering Department of Yıldız Technical University. The main activities in our laboratory are; Nanomaterials, Biomaterials, Synthesis and Characterization of Synthetic Peptides, Controlled Drug Release, Targeted Drug Delivery, Synthetic Peptide Vaccine. In a special; loading of bioactive agents to polymeric/metallic nanoparticles, solid-phase peptide synthesis, characterization of nano-systems, and chromatographic analysis/purification. Derman'S Research group is carried out their study in Biopolymers-Vaccine Lab and Bionanotechnology-Biosensors Lab.

Offer
Partner Role:
Partner
Topic of the offer:
Biosynthesis and bioactivities of nanoparticles
Other information:
Competences offered:
Biological synthesis of nanoparticles
Microbial genome mining
Antimicrobial activity tests
Offer
Partner Role:
Partner
Topic of the offer:
We are interested on the call 3 topics of the call 2020 "European Innovative Research & Technological Development Projects in Nanomedicine":
a) Regenerative medicine
b) Diagnostics
c) Targeted delivery systems
Other information:
  • First name, Surname: Elena Martin Bautista
  • Institution/organisation: Hospital Costa del Sol, Marbella, Malaga
  • Country: Spain
  • E-mail: elena.martin@hcs.es
  • Website: www.hcs.es
Competences offered:
Hospital Costa del Sol in Marbella, Malaga (Spain) is an outstanding Public Hospital attached to the Ministry of Health of the Government of Andalusia in the South of Spain. Our mission is to provide public quality health care to the citizens, seeking efficiency and optimum use of resources. Hospital Costa del Sol has 2.000 professionals and cover a population of over 470.000. We have expertise in clinical trials, epidemiological studies and health care service improvement interventions.