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Type: Search

Search
Partner Role:
Partner
Topic of the idea:
Our idea aims to develop new formulations of biomaterials composed of biomolecules, borate and phosphate groups for new generation borophosphate glasses that possess the potential of “boroapatite formation via biodegradation” for orthopedic applications.
Other information:
Description of project idea:
Organic-mediated borophosphate glasses have not been adequately investigated and are still debatable. In this study, we will search for the preparation of these glasses Detailed parametrization experiments will be performed to obtain materials with desired properties for orthopedic applications.

Already involved partners, if any (roles/competences):

-

Partners sought (roles/competences):
We are willing to join a consortium and we can contribute to this call by materials synthesis & characterization and preliminary bioactivity tests.
Cell culture tests for biocompatibility and biodegradability properties can be performed by others partners.
Search
Partner Role:
Coordinator
Topic of the idea:
Natural anti-cholinesterase enzyme inhibitors and in vivo tests. However, I am interested in research on the anti-cancer activities of new natural compounds.
Other information:
Description of project idea:
We would like to conduct in vivo trials of anti-cholinesterase enzyme inhibitors from Liquidambar Orientalis. To date, we have found that some compounds and fractions isolated from Liquidambar Orientalis drugs show very high anticholinesterase enzyme activity in vitro. We wish to test the anticholinesterase activity of these compounds and some fractions in vivo with various nanoparticles. In addition, it is another objective to test the activity of some compounds and fractions obtained from Liquidambar Orientalis resin and its fruits against Stomach and colon cancer cell lines in vivo tests. We would like to make in vivo applications of fraction and bioactive compounds that we have high activity in in vitro conditions as silver or gold nanoparticles.
Already involved partners, if any (roles/competences):

we have no partners yet.

Partners sought (roles/competences):
We are looking for partners who can contribute to our project idea. We are looking for partners who can do in vivo tests.
Search
Partner Role:
Partner
Topic of the idea:
Biocompatible monodispersed nanohydrogel with a range sizes of 20 to 500 nm for loading and delivering drugs. The system can be targeted to tumor using specific peptides and labelled with NIR probes
Other information:
Description of project idea:
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Already involved partners, if any (roles/competences):

ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Partners sought (roles/competences):
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Type: Offer

Offer
Partner Role:
Partner
Topic of the offer:
Inovenso Ltd. Co is an electrospinning company and supplier of industrial-level and laboratory-scale nanofiber production machines, with years of research and development (R&D) since 2007. It is based in Turkey, founded in Istanbul Technical University and the sister company is located at Boston-USA. Inovenso aims at providing reliable and versatile electrospinning machines with reliable technical support in research scale and industrial scale.
Other information:
  • First name, Surname: Yusuf Keskin
  • Institution/organisation: Inovenso Teknoloji Ltd Sti
  • Country: Türkiye
  • E-mail: yusuf.keskin@inovenso.com
  • Website: www.inovenso.com
Competences offered:
Nanofibers are characterized by two main properties due to its nanoscale diameter; extremely high surface to volume ratio and defects-free structure on the molecular level. These two properties make nanofibers interesting candidates in research for many applications. 1. Drug delivery systems: the versatility of composition of nanofibers and the large surface area make them excellent candidates for drug delivery particularly through the transdermal route for the delivery of different drugs as antibacterial and wound healing agents 2. Tissue engineering: nanofibers show excellent results as scaffolds for tissue regeneration. The nanofibers are usually loaded with chemicals that promote the recruitment of proliferating cells. A large amount of fabrication methods have already been demonstrated nanofibers from various materials. Compared with all of other Technologies electrospinning , has been recognized as the simple and versatile fiber-making technology for fabricating nanofibers. It is possible to produce nanofibers with electrospinning from a great variety of materials such as polymers, composites, and ceramics.
Offer
Partner Role:
Partner
Topic of the offer:
We are interested to find partners for tumor ablation using HIFU (ultrasonic technology) combined with shell core metallic nanoparticles. We are developing core shell SPIONs where the core can be loaded with cytotoxics. Use of HIFU will permit do deliver the drug on demand with a high localized payload delivery. Partners working on HIFU technology, spheroids and murin PDX models are welcome.
Other information:
  • First name, Surname: Raphaël DUVAL
  • Institution/organisation: Naturality Research & Development
  • Country: Spain
  • E-mail: naturality@sfr.fr
  • Website: wwww.naturality-essentials.net
Competences offered:
Core shell SPIONS are very promizing nano-objects with imaging properties that can be tuned by synthesis of hybrid shells (Gd doping for example). The internal core can accept in principle any type of active molecule, thus offering additional improved effciciency to the HIFU ablation effect. Concomitantly, MRI detection of the NPs in the surrounding of the tumor will help to localize the HIFU zone available for treatment.
Offer
Partner Role:
Partner
Topic of the offer:
Our idea aims to develop new formulations of biomaterials composed of biomolecules, borate and phosphate groups for new generation borophosphate glasses that possess the potential of “boroapatite formation via biodegradation” for orthopedic applications.
Other information:
Competences offered:
If there are any companies or universities interested in our idea, we would like to take part in this call and we can form consortium with any groups which are interested in a new generation borophosphate glasses for orthopedic applications. We can contribute to this call by materials synthesis & characterization and preliminary bioactivity tests.
Offer
Partner Role:
Coordinator
Topic of the offer:
Reversal of acquired drug resistance
Other information:
Competences offered:
I have experienced to generate acquired drug resistance cancer cells and to evaluate the genetic and epigenetic mechanisms leading to drug resistance, in vitro. I have an idea to overcome acquired resistance in cancer cells by spesific targeting nanoparticles. In our previous studies, we determined the reversal of different chemotherapeutic drugs based resistance by solid lipid nanoparticles. Therefore, I need collaboration for nanoparticles as well as in vivo analysis.
Offer
Partner Role:
Partner
Topic of the offer:
1. Production and characterization of multifunctional hybrid nanoparticles with defined luminescent characteristics
2. Development of novel bioanalytical platforms based on nanomaterials for highly sensitive quantification and imaging of disease biomarkers and molecules of interest in environment and food control
3. Development of optical biosensors for (bio)molecules using nanoparticles as optical tags: application to clinical, food safety control, industrial process control and environmental applications.
Other information:
  • First name, Surname: JOSE MANUEL COSTA-FERNANDEZ
  • Institution/organisation: University of Oviedo / Department of Physical and Analytical Chemistry
  • Country: Spain
  • E-mail: jcostafe@uniovi.es
  • Website: https://geab.grupos.uniovi.es/en
Competences offered:
a. Characterization of hybrid nanoparticles using molecular and elemental spectroscopic methodologies: quantification of nanoparticle number concentration and biomolecule:nanoparticle surface ligand density.

b. Development and analytical characterization of optical sensors based on nanomaterials

c. Development of multifunctional imaging nanoplatforms

d. Toxicity assessment of hybrid nanomaterials
Offer
Partner Role:
Partner
Topic of the offer:
The main idea is to transfer different amino acids, proteins or lipids to the cells, especially gamete cells like sperm and oocyte by cyclodextrins as a targeted delivery system. In addition to the potential modifications of the cell function by those delivered substances their impact on the ability of those cells to undergo freezing or cryotolerance is also in the scope. In the previous studies we have transferred cholesterol molecule to the sperm cell membrane by cholesterol preloaded cyclodextrin to improve their freezability and cell functions.
Other information:
Competences offered:
Stimulatory or modifying effects of water insoluble amino acids (AA) or lipid based components on the gamete function and their cryotolerance is not known. Their combination with cyclodextrins enhances their solubility and enable the user to deliver them on cell membrane. Formulation of different freezing protocols including these combinations (CD-AA/protein/lipid) might improve post-thaw viability of various cell lines (especially gametes).
Offer
Partner Role:
Coordinator
Topic of the offer:
We are first interested in the development and assay of nanoparticles and supramolecular nanostructures with antimicrobial properties, especially Gram-positive Streptococcus pneumoniae and Gram-negative Pseudomonas aeruginosa and Haemophilus influenzae. We have identified several compounds affecting the membrane or the cell wall of these pathogens, ranging from small organic molecules to peptides and enzymes (enzybiotics), and inducing either lytic or non-lytic effects. We would like to proceed further with their multivalent display on nanostructures, so as to increase their efficiency and to evaluate the targeting and controlled triggering of bactericidal events. In any case, we are also happy to consider participating as partners in other proposals within the call topics that might require studies on protein structure and engineering.
Other information:
Competences offered:
1.- Expertise in protein structure, stability and engineering.
2.- Biophysical studies on protein-protein and protein-ligand interactions. Spectroscopical analyses.
3.- Microbiological assays on planktonic and biofilm cultures of bacteria.
4.- Enzymes with antimicrobial activity (enzybiotics).
5.- Functionalization of polyhydroxyalkanoates (PHAs) as biodegradable and biocompatible supports for biomedical applications.
Offer
Partner Role:
Partner
Topic of the offer:
Natural products: we isolate natural anticholinesterase inhibitors and anticancer agents from plants and fungi with activity guidance. In addition, we investigate the structure-activity relationships of the molecule in natural products.
Other information:
Competences offered:
We isolate bioactive compounds from various plants and fungi as activity guided and carry out in vitro tests in our laboratory. Our laboratory and researcher infrastructure are sufficient. In addition to activity guided isolations in our laboratory, cytotoxic tests are performed against various cancer cell lines. In addition, anticholinesterase, urease, tyrosinase, alpha-glucosidase enzyme inhibition activities are investigated.
Offer
Partner Role:
Partner
Topic of the offer:
I propose an innovative anti- tumor combinatorial approach to overcome the imbalance immune effector T cells/suppressor cells to accomplish a robust and a specific CAR T cell-response against cancer.
Other information:
Competences offered:
CAR T pioneered and further developed at Prof. Eshhar’s lab, and further lead by Dr. Anat Globerson Levin. CARs are genetically engineered modular receptors that endow T cells with the ability to directly bind and attack tumor cells in a MHC-independent manner, However, a major obstacle in applying CAR T cell therapy to solid tumors is the immunosuppressive tumor microenvironment (TME). We specialized in CAR T cell against solid tumors and hematology malignancies, improving manufacturing of CAR T cell, making CAR T administration safer, making CAR T cell escape from exhaustion state.
Offer
Partner Role:
Partner
Topic of the offer:
For this or similar call
ENM Joint Transnational Call for Proposals (2020) for “European Innovative Research & Technological Development Projects in Nanomedicine”
Other information:
Competences offered:
Synthesis of novel monodispersed nanohydrogels with biocompatibility that can be targeted with peptides, labeled with NIR probes and loaded with drugs
Offer
Partner Role:
Partner
Topic of the offer:
Field of interest: 1. bone and cartilage repair/regeneration, and 2. comprehension of molecular mechanisms of osteo-chondrogenesis.

In order to revert a diseased cell phenotype, repair a damage and regenerate a tissue, we are particularly interested in the development of:
- injectable nucleic acid based drugs (siRNA, antagomiRNA, miRNA) after demonstration of the specific role of their biological target in specific cellular experimental models
- engineered cells to be used in implantable constructs (cell-based approach)
Other information:
Competences offered:
- set up of human primary cell cultures from bone, cartilage and intervertebral disc samples
- isolation and characterization of human osteoclasts from peripheral blood cells
- isolation and characterization of human mesenchymal stem cells (hMSCs) from umbilical cord Wharton Jelly
- osteoblasts/osteoclasts co-culture
- 3D cell cultures by using biomaterials, decellularized extracellular matrix, and Rotary Cell Culture System (RCCS bioreactor, SyntheconTM) with HARV (High Aspect Ratio Vessel) technology
- cell culture in controlled hypoxia environment by using X3 Hypoxia Hood And Culture Combo–BioSpherix
- gene silencing
- cell transfection
- molecular biology analysis (evaluation of gene expression, functional analysis, Luc assay, Chromatin Immunoprecipitation)
Offer
Partner Role:
Partner
Topic of the offer:
c) Targeted delivery systems
b) Diagnostics
Other information:
  • First name, Surname: Serap DERMAN
  • Institution/organisation: Yıldız Teknik Üniversitesi
  • Country: Türkiye
  • E-mail: serapacar5@gmail.com
  • Website: https://www.dermanslab.com
Competences offered:
Derman'S Functional Nano-Biomaterials and Peptide Chemistry Research Group is located in the Bioengineering Department of Yıldız Technical University. The main activities in our laboratory are; Nanomaterials, Biomaterials, Synthesis and Characterization of Synthetic Peptides, Controlled Drug Release, Targeted Drug Delivery, Synthetic Peptide Vaccine. In a special; loading of bioactive agents to polymeric/metallic nanoparticles, solid-phase peptide synthesis, characterization of nano-systems, and chromatographic analysis/purification. Derman'S Research group is carried out their study in Biopolymers-Vaccine Lab and Bionanotechnology-Biosensors Lab.

Offer
Partner Role:
Partner
Topic of the offer:
Biosynthesis and bioactivities of nanoparticles
Other information:
Competences offered:
Biological synthesis of nanoparticles
Microbial genome mining
Antimicrobial activity tests
Offer
Partner Role:
Partner
Topic of the offer:
We are interested on the call 3 topics of the call 2020 "European Innovative Research & Technological Development Projects in Nanomedicine":
a) Regenerative medicine
b) Diagnostics
c) Targeted delivery systems
Other information:
  • First name, Surname: Elena Martin Bautista
  • Institution/organisation: Hospital Costa del Sol, Marbella, Malaga
  • Country: Spain
  • E-mail: elena.martin@hcs.es
  • Website: www.hcs.es
Competences offered:
Hospital Costa del Sol in Marbella, Malaga (Spain) is an outstanding Public Hospital attached to the Ministry of Health of the Government of Andalusia in the South of Spain. Our mission is to provide public quality health care to the citizens, seeking efficiency and optimum use of resources. Hospital Costa del Sol has 2.000 professionals and cover a population of over 470.000. We have expertise in clinical trials, epidemiological studies and health care service improvement interventions.
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